IL 2 Human, Yeast
目录号 : GP20481Interleukin-2 Human Recombinant, Yeast
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 98% as determined by SDS-PAGE. | Source | Pichia pastoris. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Interleukin-2; T-cell growth factor (TCGF); Aldesleukin; Lymphokine; IL-2. | ||
| Amino Acid Sequence | A P T S S S T K K T Q L Q L E H L L L D L Q M I L N G I N N Y K N P K L T R M L T F K F Y M P K K A T E L K H L Q C L E E E L K P L E E V L N L A Q S K N F H L R P R D L I S N I N V I V L E L K G S E T T F M C E Y A D E T A T I V E F L N R W I T F C Q S I I S T L T. | ||
| Solubility | It is recommended to reconstitute the lyophilized Interleukin-2 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized Interleukin-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Interleukin-2 should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles. | ||
| Biological Activity | The biological activity is determined by the dose dependent proliferation of mouse CTLLиC2 cells. Optimal concentration for individual application should be determined by a dose response assay. ED50 range = 0.08иC0.5ng/ml | ||
| Formulation | The protein was lyophilized from a 0.2µm filtered solution in 20mM sodium phosphate buffer pH 7.0 in absence of any carrier protein. | ||
IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
The biological activity is determined by the dose dependent proliferation of mouse CTLLиC2 cells. Optimal concentration for individual application should be determined by a dose response assay. ED50 range = 0.08иC0.5ng/ml
Lyophilized Interleukin-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Interleukin-2 should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles.