IL 33 Rat, His
目录号 : GP20650Interleukin-33 Rat Recombinant, His Tag
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Interleukin-33; IL-33. | ||
| Amino Acid Sequence | MGSSHHHHHHSSGLVPRGSH MGSSIQGTSLLTESCALSTY NDQSVSFVLE NGCYVINVED CGKNQEKDKV LLRYYESSFP AQSGDGVDGK KLMVNMSPIKDTDIWLNAND KDYSVELQKG DVSPPDQAFF VLHKKSSDFV SFECKNLPGT YIGVKDNQLA LVEENDESCNNIMFKLSKM. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | IL 33 protein solution (0.5mg/ml) containing Phosphate BufferedSaline (pH7.4) and 10% glycerol. | ||
nterleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.
Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.