IL36A Mouse
目录号 : GP20660Interleukin-36 Alpha Mouse Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Interleukin 36 alpha; FIL1E; IL1F6; FIL1; IL1(EPSILON); interleukin 1 family member 6 (epsilon); MGC129552; MGC129553. | ||
| Amino Acid Sequence | MNKEKELRAA SPSLRHVQDL SSRVWILQNN ILTAVPRKEQ TVPVTITLLP CQYLDTLETN RGDPTYMGVQ RPMSCLFCTK DGEQPVLQLG EGNIMEMYNK KEPVKASLFY HKKSGTTSTF ESAAFPGWFI AVCSKGSCPL ILTQELGEIF ITDFEMIVVH | ||
| Solubility | It is recommended to reconstitute the lyophilized IL36A in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized IL36A Mouse although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL36A should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles. | ||
| Biological Activity | Measured by its binding ability in a functional ELISA to bind recombinant mouse IL-1 Rrp2. | ||
| Formulation | Lyophilized from a 0.2µm filtered concentrated solution in 1б┴PBS, pH 7.4. | ||
Murine IL-36a belongs to the IL-1 family that includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. Murine IL-36a is a 160 amino acid intracellular and secreted protein which holds no signal sequence, no prosegment and no potential N-linked glycosylation sites. IL-36a is released as a reaction to LPS and the cell ATP-induced activation of the P2X7 receptor. Mouse to human, full length IL-36a/IL-1F6 shares 54% aa sequence homology. IL-36a is mostly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine.
Measured by its binding ability in a functional ELISA to bind recombinant mouse IL-1 Rrp2.
Lyophilized IL36A Mouse although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL36A should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles.