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Impurity B of Calcitriol Sale

(Synonyms: 表骨化三醇,1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol) 目录号 : GC13663

骨化三醇的杂质 B,骨化三醇 (1,25-二羟基维生素 D3;Rocaltrol) 是维生素 D 的激素活性形式,骨化三醇是维生素 D3 的活性代谢物,可激活维生素 D 受体 (VDR)。

Impurity B of Calcitriol Chemical Structure

Cas No.:66791-71-7

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1mg
¥7,200.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).IC50 value:Target: vitamin D receptorCalcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

References:
[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)
[2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.
[3]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.
[4]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

Chemical Properties

Cas No. 66791-71-7 SDF
别名 表骨化三醇,1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol
化学名 (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Canonical SMILES CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
分子式 C27H44O3 分子量 416.64
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.4002 mL 12.0008 mL 24.0015 mL
5 mM 0.48 mL 2.4002 mL 4.8003 mL
10 mM 0.24 mL 1.2001 mL 2.4002 mL
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