Indacrinone (MK196)
(Synonyms: 茚达立酮; MK-196; Indacrynic acid) 目录号 : GC31582
Indacrinone (MK196) (MK196) 是一种研究性利尿剂，在大鼠和狗中具有明显的利尿作用，在黑猩猩中也具有排尿酸和利尿作用。
Cas No.:56049-88-8
Sample solution is provided at 25 µL, 10mM.
Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.
As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the Indacrinone (MK-196)/1 ratio is 0.8 and 5 for the urine and feces, respectively. The urinary ratio of Indacrinone/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2)[1].
[1]. A.G. ZACCHEI, et al. THE PHYSIOLOGICAL DISPOSITION
Animal experiment: | Sixteen mice are administered Indacrinone-14C. Four mice, 2 male and 2 female, are dosed orally with 10 mg/kg of drug and four additional mice (2M, 2F) are given the drug i.v. via the tail vein. In similar fashion eight additional mice are dosed with 1 mg/kg Indacrinone-14C either orally or intravenously.The animals are housed in separate metabolism cages, 2 mice of same sex per cage.The animals are fasted overnight prior to drug administration. Urine and feces are collected for the 24-hour period post drug. Animals are allowed free access to water. Urine specimens are also obtained from mice which receive Indacrinone orally at doses of 10 and 20 mg/kg/day for 9 days. On day 9 the mice are dosed and placed in metabolism cages; two cages are used per sex per group. Urine is collected during the five-hour period post last dose. A total of nineteen mice are dosed with 10 mg/kg and 18 mice are dosed with 20 mg/kg of drug[1]. |
References: [1]. A.G. ZACCHEI, et al. THE PHYSIOLOGICAL DISPOSITION | |
| Cas No. | 56049-88-8 | SDF | |
| 别名 | 茚达立酮; MK-196; Indacrynic acid | ||
| Canonical SMILES | O=C(O)COC1=CC2=C(C(C(C3=CC=CC=C3)(C)C2)=O)C(Cl)=C1Cl | ||
| 分子式 | C18H14Cl2O4 | 分子量 | 365.21 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7382 mL | 13.6908 mL | 27.3815 mL |
| 5 mM | 0.5476 mL | 2.7382 mL | 5.4763 mL |
| 10 mM | 0.2738 mL | 1.3691 mL | 2.7382 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet