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Indole-3-carboxylic acid Sale

(Synonyms: 3-吲哚甲酸) 目录号 : GC31584

A plant metabolite with diverse biological activities

Indole-3-carboxylic acid Chemical Structure

Cas No.:771-50-6

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100mg
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Sample solution is provided at 25 µL, 10mM.

Description

Indole-3-carboxylic acid is a plant metabolite derived from tryptophan that has been found in Arabidopsis and has diverse biological activities.1,2,3,4 It induces resistance in Arabidopsis against the plant necrotrophic fungus P. cucumerina when applied as a soil-drenching solution at a concentration of 150 ?M prior to infection.2 Indole-3-carboxylic acid is cytotoxic to A549 human lung and MCF-7 human breast cancer cells (EC50s = 4.6 and 12.9 ?g/ml, respectively) and inhibits HIV replication in infected H9 lymphocytes (IC50 = 16.4 ?g/ml).3 Indole-3-carboxylic acid has also been used as a precursor in the synthesis of substituted thiadiazoles with anticancer activity.4

1.Iven, T., K?nig, S., Singh, S., et al.Transcriptional activation and production of tryptophan-derived secondary metabolites in Arabidopsis roots contributes to the defense against the fungal vascular pathogen Verticillium longisporumMol. Plant5(6)1389-1402(2012) 2.Gamir, J., Pastor, V., Sánchez-Bel, P., et al.Starch degradation, abscisic acid and vesicular trafficking are important elements in callose priming by indole-3-carboxylic acid in response to Plectosphaerella cucumerina infectionPlant J.96(3)518-531(2018) 3.Wu, P.-L., Lin, F.-W., Wu, T.-S., et al.Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensisChem. Pharm. Bull. (Tokyo)52(3)345-349(2004) 4.Kumar, D., Kumar, N.M., Chang, K.-A., et al.Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazolesEur. J. Med. Chem.45(10)4664-4668(2010)

化学性质

Cas No. 771-50-6 SDF
别名 3-吲哚甲酸
Canonical SMILES O=C(O)C1=CNC2=CC=CC=C12
分子式 C9H7NO2 分子量 161.16
溶解度 DMSO: 100 mg/mL (620.50 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 6.205 mL 31.0251 mL 62.0501 mL
5 mM 1.241 mL 6.205 mL 12.41 mL
10 mM 0.6205 mL 3.1025 mL 6.205 mL
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