Indole-3-pyruvic Acid
(Synonyms: 吲哚-3-丙酮酸) 目录号 : GC47456
An endogenous metabolite of tryptophan
Cas No.:392-12-1
Sample solution is provided at 25 µL, 10mM.
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Indole-3-pyruvic acid is an endogenous metabolite of tryptophan and intermediate in the biosynthesis of the major auxin hormone, indole-3-acetic acid , in plants.[1][2][3] Indole-3-pyruvic acid (50 and 250 µM) activates the aryl hydrocarbon receptor (AhR) in a reporter assay.[1] It reduces UVB-induced cytotoxicity and the levels of COX-2 in HaCaT keratinocytes.4 Topical administration of indole-3-pyruvic acid (100 µmol) reduces the severity of UVB-induced damage in mouse skin. Dietary administration of indole-3-pyruvic acid (0.1%) reduces diarrhea, colonic inflammation, and the colonic expression of Il1b, Ifng, Tnfa, and Il12b in a mouse model of T cell-mediated colitis.[1] It increases the time spent in the open arms of the elevated plus maze in mice when administered at a dose of 100 mg/kg.[2] It also reverses the anxiogenic effect of caffeine and 3-hydroxy kynurenine, but not pentylenetetrazole or phenylethylamine, in the elevated plus maze in mice.
Reference:
[1].Aoki, R., Aoki-Yoshida, A., Suzuki, C., et al.Indole-3-pyruvic acid, an aryl hydrocarbon receptor activator, suppresses experimental colitis in miceJ. Immunol.201(12)3683-3693(2018)
[2].Lapin, I.P., and Politi, V.Anxiolytic effect of indole-3-pyruvic acid (IPA) in micePharmacol. Res.28(2)129-134(1993)
[3].Mashiguchi, K., Tanaka, K., Sakai, T., et al.The main auxin biosynthesis pathway in ArabidopsisProc. Natl. Acad. Sci. USA108(45)18512-18517(2011)
[4].Aoki, R., Aoki-Yoshida, A., Suzuki, C., et al.Protective effect of indole-3-pyruvate against ultraviolet b-induced damage to cultured HaCaT keratinocytes and the skin of hairless micePLoS One9(5)e96804(2014)
| Cas No. | 392-12-1 | SDF | |
| 别名 | 吲哚-3-丙酮酸 | ||
| 化学名 | α-oxo-1H-indole-3-propanoic acid | ||
| Canonical SMILES | O=C(C(O)=O)CC1=CNC2=CC=CC=C21 | ||
| 分子式 | C11H9NO3 | 分子量 | 203.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.9213 mL | 24.6063 mL | 49.2126 mL |
| 5 mM | 0.9843 mL | 4.9213 mL | 9.8425 mL |
| 10 mM | 0.4921 mL | 2.4606 mL | 4.9213 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet