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Influenza A virus-IN-1

目录号 : GC70644

Influenza A virus-IN-1是一种二氢吡咯烷酮衍生物,是一种针对广泛亚型甲型流感病毒(IAV)的强效抑制剂,IC50值为3.11μM至7.13μM。

Influenza A virus-IN-1 Chemical Structure

Cas No.:2250313-14-3

规格 价格 库存 购买数量
5 mg
¥720.00
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10 mg
¥1,170.00
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25 mg
¥2,385.00
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50 mg
¥3,825.00
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100 mg
¥6,120.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Influenza A virus-IN-1 is a dihydropyrrolidones derivative and is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50 values from 3.11 μM to 7.13 μM. Influenza A virus-IN-1 efficiently inhibits replication of IAV, up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA.

Influenza A virus-IN-1 (compound 5-2; 5-40 μM; 24 hours; MDCK cells) treatment significantly decreases the yields of influenza viral NP in a dose-dependent manner. And the expression level of NP protein could also be restrained in a dose-dependent manner[1].
Influenza A virus-IN-1 (compound 5-2) treatment reduces influenza HA mRNA expression at all three time points[1].
Influenza A virus-IN-1 (compound 5-2) could efficiently inhibit replication of IAV and suppress the production of the NDAPH oxidase NOX1 in MDCK cells[1].

References:
[1]. Teng Liu, et al. Discovery of Dihydropyrrolidones as Novel Inhibitors Against Influenza A Virus. Eur J Med Chem. 2020 Aug 1;199:112334.

Chemical Properties

Cas No. 2250313-14-3 SDF
分子式 C27H20F6N2O3 分子量 534.45
溶解度 DMSO : 100 mg/mL (187.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) 储存条件 4°C, stored under nitrogen
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1 mg 5 mg 10 mg
1 mM 1.8711 mL 9.3554 mL 18.7108 mL
5 mM 0.3742 mL 1.8711 mL 3.7422 mL
10 mM 0.1871 mL 0.9355 mL 1.8711 mL
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