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Ipratropium Bromide Sale

(Synonyms: 异丙托溴铵; Sch 1000) 目录号 : GC12717

A muscarinic receptor antagonist

Ipratropium Bromide Chemical Structure

Cas No.:22254-24-6

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥420.00
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50mg
¥525.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.Target: mAChRIpratropium bromide, a nonselective muscarinic antagonist, is widely prescribed for the treatment of chronic obstructive pulmonary disease (COPD). In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 g/kg); the maximum effect was obtained with 1.0 g/kg which doubled the bronchoconstriction. When the dose was increased above 1.0 g/kg potentiation no longer occurred; instead the vagally induced bronchoconstriction was antagonized [1, 2].

References:
[1]. Fryer, A.D. and J. Maclagan, Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig. Eur J Pharmacol, 1987. 139(2): p. 187-91.
[2]. Harvey, K.L., A. Hussain, and H.L. Maddock, Ipratropium Bromide-Mediated Myocardial Injury in In Vitro Models of Myocardial Ischaemia/Reperfusion. Toxicol Sci, 2014.

Chemical Properties

Cas No. 22254-24-6 SDF
别名 异丙托溴铵; Sch 1000
化学名 (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;bromide
Canonical SMILES CC(C)[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.[Br-]
分子式 C20H30BrNO3 分子量 412.37
溶解度 ≥ 20.62mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.425 mL 12.125 mL 24.2501 mL
5 mM 0.485 mL 2.425 mL 4.85 mL
10 mM 0.2425 mL 1.2125 mL 2.425 mL
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