Irigenin

Irigenin is a polyketide synthase-derived isoflavonoid that has been found in B. chinensis rhizomes and has diverse biological activities.^1,2,3,4 It inhibits the cytochrome P450 (CYP) isoform CYP1A (IC₅₀ = 1.2 ?M) and induces a 2-fold increase in NADPH quinone reductase activity in Hepa-1c1c7 cells when used at a concentration of 7.8 ?M.² Irigenin inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E₂ , as well as increases in the levels of inducible nitric oxide synthase (iNOS) and COX-2, in RAW 264.7 cells.³ In vivo, irigenin (10 and 20 mg/kg) increases survival and reduces cardiac apoptosis, fibrosis, and levels of TNF-α, IL-6, IL-18, and IL-1β in a mouse model of cardiotoxicity induced by doxorubicin .⁴

1.Raju, K.S.R., Kadian, N., Taneja, I., et al.Phytochemical analysis of isoflavonoids using liquid chromatography coupled with tandem mass spectrometryPhytochem. Rev.14(3)469–498(2015) 2.Wollenweber, E., Stevens, J.F., Klimo, K., et al.Cancer chemopreventive in vitro activities of isoflavones isolated from Iris germanicaPlanta Med.69(1)15-20(2003) 3.Ahn, K.S., Noh, E.J., Cha, K.-H., et al.Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglandin E2 production in murine macrophage RAW 264.7 cellsLife Sci.78(20)2336-2342(2006) 4.Guo, L., Zheng, X., Wang, E., et al.Irigenin treatment alleviates doxorubicin (DOX)-induced cardiotoxicity by suppressing apoptosis, inflammation and oxidative stress via the increase of miR-425Biomed. Pharmacother.125109784(2020)