Isethionic acid
(Synonyms: 2-羟乙基磺酸,2-Hydroxyethanesulfonic acid) 目录号 : GC60941
Isethionicacid(2-Hydroxyethanesulfonicacid)是一种有机硫化合物。Isethionicacid广泛分布于动物和一些红色藻类植物中。Isethionicacid可用作阴离子去污剂，对Balanusamphitrite具有抗沉降活性。
Cas No.:107-36-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Isethionic acid (2-Hydroxyethanesulfonic acid) is an organosulfur compound. Isethionic acid is widely distributed in animal species and in a few red algal species. Isethionic acid can be used as an anionic detergent and has anti-settlement activity against Balanus amphitrite[1][2].
[1]. Hellio C, et al. Isethionic acid and floridoside isolated from the red alga, Grateloupia turuturu, inhibit settlement of Balanus amphitrite cyprid larvae. Biofouling. 2004 Jun;20(3):139-45. [2]. Tupker RA, et al. Irritancy ranking of anionic detergents using one-time occlusive, repeated occlusive and repeated open tests. Contact Dermatitis. 1999 Jun;40(6):316-22.
| Cas No. | 107-36-8 | SDF | |
| 别名 | 2-羟乙基磺酸,2-Hydroxyethanesulfonic acid | ||
| Canonical SMILES | O=S(CCO)(O)=O | ||
| 分子式 | C2H6O4S | 分子量 | 126.13 |
| 溶解度 | DMSO : 100 mg/mL (792.83 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 7.9283 mL | 39.6416 mL | 79.2833 mL |
| 5 mM | 1.5857 mL | 7.9283 mL | 15.8567 mL |
| 10 mM | 0.7928 mL | 3.9642 mL | 7.9283 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Isethionic acid and floridoside isolated from the red alga, Grateloupia turuturu, inhibit settlement of Balanus amphitrite cyprid larvae
Biofouling 2004 Jun;20(3):139-45.PMID:15545063DOI:10.1080/08927010412331279605.
Isethionic acid (2-hydroxyethane sulfonic acid) and floridoside (2-O-alpha-D-galactopyranosylglycerol) were extracted from the red alga, Grateloupia turuturu, and tested for anti-settlement activity against cyprid larvae of the tropical barnacle, Balanus amphitrite and for their toxicity to nauplius larvae. Isethionic acid was active for anti-settlement but had the disadvantage of being toxic to nauplius larvae. Floridoside was a potent inhibitor of cyprid settlement at non-toxic concentrations to nauplii (0.01 mg ml(-1)).
Identification of Isethionic acid and other small molecule metabolites of Fragilariopsis cylindrus with nuclear magnetic resonance
Anal Bioanal Chem 2012 Aug;404(3):777-84.PMID:22772138DOI:10.1007/s00216-012-6169-2.
Nuclear magnetic resonance (NMR) spectroscopy has been used to obtain metabolic profiles of the polar diatom Fragilariopsis cylindrus, leading to the identification of a novel metabolite in this organism. Initial results from an ongoing metabolomics study have led to the discovery of Isethionic acid (2-hydroxyethanesulfonic acid, CAS: 107-36-8) as a major metabolite in F. cylindrus. This compound is being produced by the organism under normal culture conditions. This finding is the first report of a diatom producing Isethionic acid. In addition to Isethionic acid, four other metabolites, dimethylsulfoniopropionate (DMSP), betaine, homarine, and proline were present and may serve as osmoprotectants in F. cylindrus. NMR-based metabolite profiles of F. cylindrus were obtained along a growth curve of the organism. The relative concentration levels of the five metabolites were monitored over a growth period of F. cylindrus from 18 to 25 days. All showed an increase in relative concentration with time, except for proline, which began to decrease after day 21.
The ethanol-induced open-field activity in rodents treated with Isethionic acid, a central metabolite of taurine
Life Sci 1999;64(18):1613-21.PMID:10328521DOI:10.1016/s0024-3205(99)00098-3.
The effect of Isethionic acid, a central metabolite of taurine, on ethanol-induced locomotor activity was investigated in rodents. Ten minutes following an (i.p.) simultaneous administration of ethanol (0.0, 1.5, 2.0, 2.5, 3.0, 3.5 g/kg) and Isethionic acid (0.0, 22.5, 45.0, 90.0, 180.0 mg/kg), mice were placed in the open-field chambers and locomotor activity was measured during a ten-minute testing period. A significant interaction was found between Isethionic acid and ethanol. Isethionic acid pre-treated mice (45.0, 90.0 and 180.0 mg/kg) showed a higher locomotor activity than the saline group at 2.5 and 3 g/kg of ethanol. In a second study, Isethionic acid (45 mg/kg) and ethanol (1 g/kg) were simultaneously injected to rats. Ten minutes after the two treatments, rats were placed in the open-field chamber for a 30-minute period. The depressant effects that ethanol produced on rat locomotion were amplified by the same dose of Isethionic acid as it affected ethanol-induced locomotion in mice (45 mg/kg). However, Isethionic acid did not change the spontaneous locomotion at any of the doses tested in mice or rats. Since no differences in blood ethanol levels were detected in both mice and rats, the interaction between Isethionic acid's action and ethanol-related locomotion does not seem to be due to different rates of absorption of ethanol or any other pharmacokinetic process related to ethanol levels. The current study displayed that Isethionic acid, administered intraperitoneally, behaves in a similar way to its immediate precursor, taurine, by amplifying ethanol-induction of the locomotor activity.
Electrophoretic determination of taurine
J Chromatogr A 2021 May 24;1645:462075.PMID:33848661DOI:10.1016/j.chroma.2021.462075.
An electrophoretic method (on-line coupled capillary isotachophoresis and capillary zone electrophoresis) with conductometric detection for the determination of free taurine in selected food and feed is described. Taurine is converted to Isethionic acid by van Slyke method. Under optimized conditions (leading electrolyte: 5 mM HCl, 10 mM glycylglycine, and 0.05% 2-hydroxyethyl cellulose solution, pH 3.2; terminating electrolyte: 10 mM citric acid; background electrolyte: 50 mM acetic acid, 20 mM glycylglycine, and 0.1% 2-hydroxyethyl cellulose solution, pH 3.7), Isethionic acid is separated from other sample components in anionic mode and detected using a conductimeter within 15 minutes. The performance method characteristics, such as linearity (25 - 1250 ng/mL), accuracy (99 ± 9%), repeatability (3.9%), reproducibility (4.3%), limits of detection (3 ng/mL) and quantification (10 ng/mL) were evaluated. By analysing 20 food and pet food samples the method was proved suitable for routine analysis. High sensitivity and selectivity, short analysis time and low costs are significant features of the presented method.
Enzymatic oxidation of mercaptoethanol to isethinic acid and Isethionic acid
Enzyme 1978;23(5):307-13.PMID:213263DOI:10.1159/000458594.
The enzymatic oxidation of mercaptoethanol by purified cysteamine oxygenase has been studied. Products were identified by chromatography as isethinic acid (2-hydroxyethan-sulfinic acid) and Isethionic acid. Other features of the reaction, as cofactor requirement, the influence of the enzyme concentration on the stage of oxidation, the biological significance of this reaction are also discussed.