Isoborneol
(Synonyms: 异龙脑; (±)-Isoborneol) 目录号 : GC40668
A monoterpene alcohol
Cas No.:124-76-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Isoborneol is a monoterpene alcohol that has been found in a variety of plants, including C. sativa, C. indica, and C. sativa/C. indica hybrid strains, with neuroprotective and antiviral activities. It reduces SH-SY5Y cell death induced by 6-OHDA when used at concentrations ranging from 2.5 to 10 μM via inhibition of apoptosis, reducing increases in intracellular levels of reactive oxygen species (ROS), and preventing decreases in the mitochondrial membrane potential. Isoborneol (0.03 and 0.06%) reduces HSV-1 viral replication by inhibiting viral protein synthesis. It inhibits the glycosylation of HSV-1 glycoprotein gB but has no effect on protein glycosylation in Vero cells.
| Cas No. | 124-76-5 | SDF | |
| 别名 | 异龙脑; (±)-Isoborneol | ||
| Canonical SMILES | C[C@]1(C2(C)C)CC[C@@H]2C[C@H]1O | ||
| 分子式 | C10H18O | 分子量 | 154.3 |
| 溶解度 | DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 15 mg/ml,Ethanol: 15 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.4809 mL | 32.4044 mL | 64.8088 mL |
| 5 mM | 1.2962 mL | 6.4809 mL | 12.9618 mL |
| 10 mM | 0.6481 mL | 3.2404 mL | 6.4809 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Isoborneol as a natural sporulation quenching agent to control Aspergillus flavus
Nat Prod Res 2022 Sep 19;1-5.PMID:36121695DOI:10.1080/14786419.2022.2124988.
In an effort to seek natural antisporulating agents used in the control of Aspergillus flavus, 54 essential oil compounds were employed to evaluate their antisporulating activity against A. flavus at the concentration of 100 μg/mL. The results indicated that Isoborneol could inhibit spore production at 100 μg/mL. The light microscopy and scanning electron microscopy (SEM) observations revealed that A. flavus did not produce any conidia, vesicles, phialides and conidiophores after treatment with Isoborneol at 80 μg/mL, confirming the effectiveness of Isoborneol. The in vivo bioassay results demonstrated that Isoborneol could prevent the peanuts from A. flavus contamination by inhibiting the sporulation when treated with Isoborneol at concentrations higher than 100 μg/mL. RT-qPCR results suggested that Isoborneol exerts its antisporulating activity by suppressing the fluG expression. These results proved that Isoborneol could be used as a natural and safe antisporulating agent for commercial applications to control spore infections of A. flavus.
Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages
Drug Des Devel Ther 2020 Jan 15;14:167-173.PMID:32021101DOI:10.2147/DDDT.S233013.
Purpose: Isoborneol has been used in the treatment of cardiovascular disease for several years in China. However, the mechanism is still unclear. The aim of this study was to identify the novel mechanism of Isoborneol for its application in atherosclerotic disease. Materials and methods: The whole-genome gene expression profiles of MCF-7 cells treated with/or without Isoborneol were detected by mRNA microarray analysis. The degree of similarity between the gene expression profiles was compared with the Connectivity Map (CMAP) database. An MTT assay was used to assess the toxicity of Isoborneol on RAW 264.7 cells. Oil red O staining and a Dil-ox-LDL uptake assay in RAW 264.7 cells were also used to detect the accumulation of lipids in the macrophages and the uptake of oxidized low-density lipoprotein (ox-LDL). Results: Isoborneol was proved to have mRNA expression profiles similar to that of ikarugamycin which can inhibit the uptake of ox-LDL. This process has proved to be an important cause of foam cell formation and early atherosclerotic lesions. It is speculated, therefore, that Isoborneol may show similar activity to that shown by ikarugamycin. Subsequently, it was shown that RAW 264.7 cells reduced the absorption of ox-LDL and the accumulation of intracellular lipids after treatment with different concentrations of Isoborneol. Conclusion: The results indicate that Isoborneol inhibits macrophage consumption of ox-LDL, thereby preventing the accumulation of lipids in the macrophages. These results provide evidence for the application of Isoborneol in atherosclerotic disease.
Fragrance material review on Isoborneol
Food Chem Toxicol 2008 Nov;46 Suppl 11:S182-4.PMID:18640231DOI:10.1016/j.fct.2008.06.052.
A toxicologic and dermatologic review of Isoborneol when used as a fragrance ingredient is presented.
RIFM fragrance ingredient safety assessment, Isoborneol, CAS Registry Number 124-76-5
Food Chem Toxicol 2015 Oct;84 Suppl:S33-41.PMID:26291250DOI:10.1016/j.fct.2015.08.011.
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NOAEL of 15 mg/kg/day based on a gavage 13-week subchronic toxicity study conducted in rats on a read across analog resulting in a MOE of 1000 considering 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.
Auto-Disinfectant Acrylic Paints Functionalised with Triclosan and Isoborneol-Antibacterial Assessment
Polymers (Basel) 2021 Jul 1;13(13):2197.PMID:34279341DOI:10.3390/polym13132197.
Environmental surface contamination with microorganisms is a serious concern worldwide. Triclosan and Isoborneol present good antimicrobial activity. Their immobilisation to paint substrates allows for development of a material that stays effective over a longer time. In this work, we disclosed the preliminary studies to evaluate the antimicrobial activity of the active molecule after being functionalised with isocyanates for further immobilisation on the paint substrate. Overall, the newly developed non-release antimicrobial coating provides an effective way of preventing the spread of diseases and has been proven to inhibit bacterial growth and with a considerable antimicrobial activity towards S. aureus, E. coli, and K. variicola at the tested concentrations.