Isoguanine
(Synonyms: 异鸟嘌呤) 目录号 : GC33662
An isomer of guanine
Cas No.:3373-53-3
Sample solution is provided at 25 µL, 10mM.
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Isoguanine is a natural isomer of guanine originally isolated from Croton seed but is also a product of oxidative damage to the adenine base in DNA.1,2 It can be formed through oxidative damage to deoxyadenosine and deoxyadenosine-ATP (d-ATP) as well as single- and double-stranded DNA and induces a parallel-stranded DNA structure when incorporated into DNA.2,3 It is mutagenic to S. tymphimurium in the Ames test and induces sister chromatid exchange, a measure of mutagenicity, in isolated human peripheral blood lymphocytes.4
1.Cherbuliez, E., and Bernhard, K.Croton seed. I. Crotonoside (2-hydroxy-6-aminopurine-d-riboside)Helv. Chim. Acta15464-471(1932) 2.Cheng, Q., Gu, J., Compaan, K.R., et al.Isoguanine formation from adenineChemistry18(16)4877-4886(2012) 3.Kamiya, H., and Kasai, H.2-Hydroxyadenine (isoguanine) as oxidative DNA damage: Its formation and mutation inducibilityNucleic Acids Symp. Ser.(34)233-234(1995) 4.Arashidani, K., Iwamoto-Tanaka, N., Muraoka, M., et al.Genotoxicity of ribo- and deoxyribonucleosides of 8-hydroxyguanine, 5-hydroxycytosine, and 2-hydroxyadenine: Induction of SCE in human lymphocytes and mutagenicity in Salmonella typhimurium TA 100Mutat. Res.403(1-2)223-227(1998)
| Cas No. | 3373-53-3 | SDF | |
| 别名 | 异鸟嘌呤 | ||
| Canonical SMILES | NC1=NC(NC2=C1NC=N2)=O | ||
| 分子式 | C5H5N5O | 分子量 | 151.13 |
| 溶解度 | 1 M NaOH: *50 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.6168 mL | 33.0841 mL | 66.1682 mL |
| 5 mM | 1.3234 mL | 6.6168 mL | 13.2336 mL |
| 10 mM | 0.6617 mL | 3.3084 mL | 6.6168 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet