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Isomucronulatol 7-O-glucoside Sale

(Synonyms: 黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷,Isomucronulatol 7-O-β-glucoside) 目录号 : GC39035

Isomucronulatol 7-O-glucoside 在体外对 LPS 刺激产生的 IL-12 p40 有微弱的抑制作用,具有潜在的抗炎作用。

Isomucronulatol 7-O-glucoside Chemical Structure

Cas No.:136087-29-1

规格 价格 库存 购买数量
5mg
¥1,620.00
现货
10mg
¥2,700.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Isomucronulatol 7-O-glucoside is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol 7-O-glucoside exhibits weak inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect[1].

[1]. Li W, et al. Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells. Arch Pharm Res. 2014 Feb;37(2):186-92.

Chemical Properties

Cas No. 136087-29-1 SDF
别名 黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷,Isomucronulatol 7-O-β-glucoside
Canonical SMILES OC1=C([C@H]2CC3=CC=C(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO)C=C3OC2)C=CC(OC)=C1OC
分子式 C23H28O10 分子量 464.46
溶解度 DMSO : 100 mg/mL (215.30 mM; Need ultrasonic) 储存条件 4°C, protect from light
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.153 mL 10.7652 mL 21.5304 mL
5 mM 0.4306 mL 2.153 mL 4.3061 mL
10 mM 0.2153 mL 1.0765 mL 2.153 mL
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Research Update

UPLC-ESI-Q-TOF-MS-Based Metabolite Profiling, Antioxidant and Anti-Inflammatory Properties of Different Organ Extracts of Abeliophyllum distichum

Antioxidants (Basel) 2021 Jan 7;10(1):70.PMID:33430473DOI:10.3390/antiox10010070.

Plant extracts have gained more attention as natural therapeutic agents against inflammation characterized by an overproduction of several inflammatory mediators such as reactive oxygen species and pro-inflammatory cytokines. Although Abeliophyllum distichum Nakai is generally known for its ornamental value, recent pharmacological research has demonstrated its potential therapeutic properties. Thus, to further evaluate the applicability of A. distichum in the food, cosmetic, and medical industries, we identified the phytochemicals in three organ extracts (fruits: AF, branches: AB, leaves: AL) of A. distichum and determined their antioxidant and anti-inflammatory activities. Using UPLC-ESI-Q-TOF-MS, a total of 19 compounds, including dendromoniliside D, forsythoside B, isoacteoside, Isomucronulatol 7-O-glucoside, plantamajoside, and wighteone were identified in the A. distichum organ extracts. AB exhibited a strong reducing power, an oxygen radical antioxidant capacity, and radical scavenging values compared with other samples, whereas AL exhibited the best anti-inflammatory properties. Gene expression, western blot, and molecular docking analyses suggested that the anti-inflammatory effect of AL was mediated by its ability to suppress lipopolysaccharide (LPS)-induced production of reactive oxygen species and/or inhibit LPS-stimulated activation of extracellular signal-regulated protein kinases (ERK1/2) in RAW264.7 cells. Collectively, these results indicate that AL is a potential source of phytochemicals that could be used to treat inflammation-associated diseases.