Isovaleryl-L-carnitine-d3 (chloride)
(Synonyms: CAR 5:0-d3, C5:0 Carnitine-d3, L-Carnitine isovaleryl ester-d3, L-Isovalerylcarnitine-d3) 目录号 : GC47470
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Isovaleryl-L-carnitine-d3 is intended for use as an internal standard for the quantification of isovaleryl-L-carnitine by GC- or LC-MS. Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolism of L-leucine.1 It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM.2 Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively.3 Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).4
1.Cavazza, C.L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis(1993) 2.Revoltella, R.P., Dal Canto, B., Caracciolo, L., et al.L-carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivationBiochim. Biophys. Acta1224(3)333-341(1994) 3.Miotto, G., Venerando, R., Khurana, K.K., et al.Control of hepatic proteolysis by leucine and isovaleryl-L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma membraneJ. Biol. Chem.267(31)22066-22072(1992) 4.Rinaldo, P., Cowan, T.M., and Matern, D.Acylcarnitine profile analysisGenet.Med.10(2)151-156(2008)
| Cas No. | N/A | SDF | |
| 别名 | CAR 5:0-d3, C5:0 Carnitine-d3, L-Carnitine isovaleryl ester-d3, L-Isovalerylcarnitine-d3 | ||
| Canonical SMILES | OC(C[C@H](C[N+](C([2H])([2H])[2H])(C)C)OC(CC(C)C)=O)=O.[Cl-] | ||
| 分子式 | C12H21D3NO4.Cl | 分子量 | 284.8 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5112 mL | 17.5562 mL | 35.1124 mL |
| 5 mM | 0.7022 mL | 3.5112 mL | 7.0225 mL |
| 10 mM | 0.3511 mL | 1.7556 mL | 3.5112 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet