Home>>Signaling Pathways>> GPCR/G protein>> Adrenergic Receptor>>Isoxsuprine (hydrochloride)

Isoxsuprine (hydrochloride) Sale

(Synonyms: 异舒普林盐酸盐;盐酸异克舒令) 目录号 : GC17998

An adrenergic receptor modulator

Isoxsuprine (hydrochloride) Chemical Structure

Cas No.:579-56-6

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥462.00
现货
200mg
¥350.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

Description

Isoxsuprine is a modulator of β2 adrenoreceptor and has agonist or antagonist effects.

The β2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine. Many cells possess these receptors, the binding of epinephrine to the receptor will generally stimulates the sympathetic nervous system, resulting in muscle relaxation, vasodilation, diverting blood flow from non-essential organs to skeletal muscle and mobilizing energy [1].

As a modulator of β2 adrenoreceptor, Isoxsuprine is used as a vasodilator as well as smooth muscle modifier in humans. In vitro neuroprotection experiment, when administered up to an hour after reoxygenation, Isoxsuprine demonstrated no loss of neuron efficacy [2]..

In vivo animal stroke model, 1 mg/kg isoxsuprine was administered after a 90-minute occlusion of the right middle cerebral artery by IV injection at reperfusion. Total infarct volume in isoxsuprine-treated group was 137±18 mm3 compared to 279±25 mm3 in control group [2].

References:
1.  R. S. Ekert and C. G. Macallister. Isoxsuprine hydrochloride in the horse: A review. J. Vet. Pharmacol. Ther. 2002, 25(2), 81-87
2.  Hill JW, Thompson JF, Carter MB. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7; 9(5):e96761

化学性质

Cas No. 579-56-6 SDF
别名 异舒普林盐酸盐;盐酸异克舒令
化学名 4-hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-benzenemethanol, monohydrochloride
Canonical SMILES OC1=CC=C(C(O)C(C)NC(C)COC2=CC=CC=C2)C=C1.Cl
分子式 C18H23NO3 • HCl 分子量 337.8
溶解度 ≥ 16.3mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.9603 mL 14.8017 mL 29.6033 mL
5 mM 0.5921 mL 2.9603 mL 5.9207 mL
10 mM 0.296 mL 1.4802 mL 2.9603 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置

产品文档

Quality Control & SDS

View current batch: