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Itraconazole-d3

(Synonyms: R51211-d3) 目录号 : GC68281

Itraconazole-d3 (R51211-d3) 是 Itraconazole 的氘代物。

Itraconazole-d3 Chemical Structure

Cas No.:1217512-35-0

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5mg
¥8,910.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Itraconazole-d3 (R51211-d3) is the deuterium labeled Itraconazole [1].

[1]. Dwivedi A, et al. Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma. J Pharm Anal. 2014 Oct;4(5):316-324.

Chemical Properties

Cas No. 1217512-35-0 SDF Download SDF
别名 R51211-d3
分子式 C35H35D3Cl2N8O4 分子量 708.65
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1 mM 1.4111 mL 7.0557 mL 14.1113 mL
5 mM 0.2822 mL 1.4111 mL 2.8223 mL
10 mM 0.1411 mL 0.7056 mL 1.4111 mL
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Research Update

Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma

J Pharm Anal 2014 Oct;4(5):316-324.PMID:29403895DOI:PMC5761207

A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquid-liquid extraction step. The precursor to product ion transitions of m/z 705.3/392.3, m/z 721.2/408.3 and m/z 708.2/435.4 were used to detect and quantify itraconazole, hydroxy itraconazole and Itraconazole-d3 respectively. The lower limit of quantitation was found to be 0.500 ng/mL for itraconazole and 1.00 ng/mL for hydroxy itraconazole. The mean recoveries for itraconazole and hydroxy itraconazole were found to be 100.045% and 100.021%, respectively. This developed method with a chromatographic run time of 2.0 min was successfully applied to a bioequivalence study of 100 mg itraconazole capsule.