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Janthitrem A Sale

(Synonyms: 11,12-Epoxyjanthitrem B) 目录号 : GC47476

A mycotoxin

Janthitrem A Chemical Structure

Cas No.:73561-89-4

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500 μg
¥2,141.00
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2.5 mg
¥9,645.00
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产品描述

Janthitrem A is a mycotoxin that has been found in P. janthinellum.1 It induces tremors in mice and decreases the time to fall from the rotarod when administered at a dose of 4 mg/kg.2 Janthitrem A (20 µg/g) also reduces W. cervinata larvae weight gain and food consumption.

1.Gallagher, R.T., Latch, G.C., and Keogh, R.G.The janthitrems: Fluorescent tremorgenic toxins produced by Penicillium janthinellum isolates from ryegrass pasturesAppl. Environ. Microbiol.39(1)272-273(1980) 2.Babu, J.V., Popay, A.J., Miles, C.O., et al.Identification and structure elucidation of janthitrems A and D from Penicillium janthinellum and determination of the tremorgenic and anti-insect activity of janthitrems A and BJ. Agric. Food Chem.66(50)13116-13125(2018)

Chemical Properties

Cas No. 73561-89-4 SDF
别名 11,12-Epoxyjanthitrem B
Canonical SMILES CC1(C)[C@@](C2=CC(C)(C)O1)([H])[C@H](O)C(C2=C3)=CC4=C3NC5=C4C[C@@]6([H])[C@@]5(C)[C@](CC[C@@]7([H])[C@]8(O9)[C@H]9[C@@H](O)[C@@H](C(C)=C)O7)(C)[C@@]8(O)CC6
分子式 C37H47NO6 分子量 601.8
溶解度 DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble 储存条件 Store at -20°C
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1 mM 1.6617 mL 8.3084 mL 16.6168 mL
5 mM 0.3323 mL 1.6617 mL 3.3234 mL
10 mM 0.1662 mL 0.8308 mL 1.6617 mL
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Research Update

Identification and Structure Elucidation of Janthitrems A and D from Penicillium janthinellum and Determination of the Tremorgenic and Anti-Insect Activity of Janthitrems A and B

J Agric Food Chem 2018 Dec 19;66(50):13116-13125.PMID:30482018DOI:10.1021/acs.jafc.8b04964.

New compounds, 11,12-epoxyjanthitrem B (1) and 11,12-epoxyjanthitrem C (4), were isolated from Penicillium janthinellum and given the trivial names Janthitrem A and janthitrem D, respectively. The known compounds janthitrem B (2) and janthitrem C (3) were also isolated, and NMR assignments were made for all four compounds. This showed that the previously published NMR assignments for 3 needed considerable revision. 1 and 2 were used as model compounds for the more complex, and highly unstable, epoxyjanthitrems that have been isolated from perennial ryegrass infected with the AR37 endophyte and which contain an epoxide group analogous to that of 1. Both 1 and 2 induced tremors in mice and reduced weight gain and food consumption of porina ( Wiseana cervinata) larvae, although 1 showed greater potency. This shows the importance of the epoxy group and suggests that epoxyjanthitrems are likely to be involved in the observed effects of the AR37 endophyte on livestock and insects.

The Known Antimammalian and Insecticidal Alkaloids Are Not Responsible for the Antifungal Activity of Epichloë Endophytes

Plants (Basel) 2021 Nov 17;10(11):2486.PMID:34834850DOI:10.3390/plants10112486.

Asexual Epichloë sp. endophytes in association with pasture grasses produce agronomically important alkaloids (e.g., lolitrem B, epoxy-janthitrems, ergovaline, peramine, and lolines) that exhibit toxicity to grazing mammals and/or insect pests. Novel strains are primarily characterised for the presence of these compounds to ensure they are beneficial in an agronomical setting. Previous work identified endophyte strains that exhibit enhanced antifungal activity, which have the potential to improve pasture and turf quality as well as animal welfare through phytopathogen disease control. The contribution of endophyte-derived alkaloids to improving pasture and turf grass disease resistance has not been closely examined. To assess antifungal bioactivity, nine Epichloë related compounds, namely peramine hemisulfate, n-formylloline-d3, n-acetylloline hydrochloride, lolitrem B, Janthitrem A, paxilline, terpendole E, terpendole C, and ergovaline, and four Claviceps purpurea ergot alkaloids, namely ergotamine, ergocornine, ergocryptine, and ergotaminine, were tested at concentrations higher than observed in planta in glasshouse and field settings using in vitro agar well diffusion assays against three common pasture and turf phytopathogens, namely Ceratobasidium sp., Drechslera sp., and Fusarium sp. Visual characterisation of bioactivity using pathogen growth area, mycelial density, and direction of growth indicated no inhibition of pathogen growth. This was confirmed by statistical analysis. The compounds responsible for antifungal bioactivity of Epichloë endophytes hence remain unknown and require further investigation.

The janthitrems: fluorescent tremorgenic toxins produced by Penicillium janthinellum isolates from ryegrass pastures

Appl Environ Microbiol 1980 Jan;39(1):272-3.PMID:7356319DOI:10.1128/aem.39.1.272-273.1980.

New tremorgenic mycotoxins named Janthitrem A, B, and C (molecular weights 601, 585, and 569, respectively) were produced by more than half of 21 Penicillium janthinellum isolates obtained from ryegrass pastures involved in ryegrass staggers outbreaks in sheep.