JMJD6 Human
目录号 : GP23725Jumonji Domain Containing 6 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
;)
_1-7.$$$37316672@70.jpg');)
;)
;)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
;)
;)
;)
_1124-1138.$$$35908550@30.jpg');)
_766-780.$$$37100057@30.jpg');)
_418-432.$$$36893736@30.jpg');)
_240-255.$$$35108512@29.jpg');)
_533-545.$$$36543525@28.jpg');)
_264-276.$$$36600053@22.jpg');)
_2214998.$$$@0.jpg');)
| Purity | Greater than 90% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Jumonji Domain Containing 6; Phosphatidylserine Receptor;Jumonji Domain-Containing Protein 6; Histone Arginine Demethylase JMJD6; Peptide-Lysine5-Dioxygenase JMJD6; JmjC Domain-Containing Protein 6; Lysyl-Hydroxylase JMJD6;PTDSR; PSR; Bifunctional Arginine Demethylase And Lysyl-Hydroxylase JMJD6;Protein PTDSR; EC 1.14.11.-; EC 1.14.11; KIAA0585; PTDSR1; Bifunctionalarginine demethylase and lysyl-hydroxylase JMJD6 (EC:1.14.11.-). | ||
| Amino Acid Sequence | MGSSHHHHHHSSGLVPRGSH MGSMNHKSKKRIREAKRSAR PELKDSLDWT RHNYYESFSL SPAAVADNVE RADALQLSVE EFVERYERPY KPVVLLNAQE GWSAQEKWTLERLKRKYRNQ KFKCGEDNDG YSVKMKMKYY IEYMESTRDD SPLYIFDSSY GEHPKRRKLL EDYKVPKFFTDDLFQYAGEK RRPPYRWFVM GPPRSGTGIH IDPLGTSAWN ALVQGHKRWC LFPTSTPREL IKVTRDEGGNQQDEAITWFN VIYPRTQLPT WPPEFKPLEI LQKPGETVFV PGGWWHVVLN LDTTIAITQN FASSTNFPVVWHKTVRGRPK LSRKWYRILK QEHPELAVLA DSVDLQESTG IASDSSSDSS SSSSSSSSDS DSECESGSEGDGTVHRRKKR RTCSMVGNGD TTSQDDCVSK ERSSSRIRDT CGGRAHP. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | JMJD6 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 30% glycerol and 1mM DTT. | ||
Jumonji Domain Containing 6, also known as JMJD6 performs as alysyl-hydroxylase which catalyzes 5-hydroxylation on specific lysine residuesof target proteins for instance U2AF2/U2AF65 and LUC7L2, as a regulator of RNA splicing by mediating 5-hydroxylation ofU2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Additionallyto peptidyl-lysine 5-dioxygenase activity, JMJD6 performs as an RNAhydroxylase, as proposed by its ability to bind single strand RNA. Furthermore,it acts as an arginine demethylase which demethylates histone H3 at 'Arg-2'(H3R2me) as well as histone H4 at 'Arg-3' (H4R3me), thus taking a part in histone code.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.