JWH 073 N-(4-hydroxybutyl) metabolite-d5

JWH 073 N-(4-hydroxybutyl) metabolite-d₅ contains five deuterium atoms at the 2', 4' ,5', 6', and 7' positions. It is intended for use as an internal standard for the quantification of JWH 073 N-(4-hydroxybutyl) metabolite by GC- or LC-MS. JWH 073 is a mildly selective agonist of the central cannabinoid (CB₁) receptor derived from the aminoalkylindole WIN 55,212-2. The K_i values for binding CB₁ and the peripheral cannabinoid (CB₂) receptor are 8.9 and 38 nM, respectively for a CB₁:CB₂ ratio of 0.23.¹ JWH 073 is one of several synthetic CBs which have been included in smoking mixtures. JWH 073 N-(4-hydroxybutyl) metabolite is expected to be a major urinary metabolite of JWH 073, characterized by monohydroxylation of the N-alkyl chain, based on the metabolism of the closely-related JWH 015 and JWH 018.^2,3 In urine samples, this metabolite of JWH 018 is almost completely glucuronidated.³

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