Kassinin (frog) (trifluoroacetate salt)
目录号 : GC91842Kassinin is a tachykinin neuropeptide and agonist of the neurokinin-2 (NK2) and NK3 receptors.
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Kassinin is a tachykinin neuropeptide and agonist of the neurokinin-2 (NK2) and NK3 receptors.1,2,3,4 It is selective for the NK2 and NK3 receptors over the NK1 receptor.4 Kassinin (1 µM) increases the short-circuit current in isolated frog skin.5 It induces contractions in isolated guinea pig ileum and isolated rabbit jejunum in a concentration-dependent manner.3 Kassinin decreases blood pressure in anesthetized guinea pigs (ED50 = 1,832 pmol/kg).2
References:
[1].Anastasi, A., Montecucchi, P., Erspamer, V., et al.Amino acid composition and sequence of kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensisExperientia33(7)857-858(1977).
[2].Hancock, J.C., and Hoover, D.B.Effect of substance P and other tachykinins on arterial pressure in guinea-pigsJ. Auton. Pharmacol.5(1)25-30(1985).
[3].Holzer-Petsche, U., Schimek, E., Amann, R., et al.In vivo and in vitro actions of mammalian tachykininsNaunyn Schmiedebergs Arch. Pharmacol.330(2)130-135(1985).
[4].Regoli, D., Drapeau, G., Dion, S., et al.New selective agonists for neurokinin receptors: pharmacological tools for receptor characterizationTrends Pharmacol. Sci.9(8)290-295(1988).
[5].Lippe, C., Bellantuono, V., Ardizzone, C., et al.Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skinPeptides25(11)1971-1975(2004).
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.7493 mL | 3.7464 mL | 7.4929 mL |
| 5 mM | 0.1499 mL | 0.7493 mL | 1.4986 mL |
| 10 mM | 0.0749 mL | 0.3746 mL | 0.7493 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。