Keracyanin (chloride)
(Synonyms: 花青素鼠李葡糖苷,Cyanidin 3-rutinoside) 目录号 : GC43998A natural antioxidant
Cas No.:18719-76-1
Sample solution is provided at 25 µL, 10mM.
Keracyanin (chloride) is a polyphenolic anthocyanin found naturally in many plants. It has high antioxidant activity, protecting erythrocytes from apoptosis. [1] [2] However, keracyanin (chloride) impairs growth and induces apoptosis in the highly tumorigenic RE-149 DHD cell line. [3] It inhibits a range of mammalian and bacterial proteases, including neutrophil elastase, matrix metalloproteinase-1 (MMP-1), and MMP-9 at concentrations of 6.25-50 µg/ml. [4] When added to food, keracyanin (chloride) significantly reduces body weight gain, resistance to insulin, and lipid accumulation in mice fed a high-fat diet. [5]
Reference:
[1]. Tyl, C.E., and Bunzel, M. Antioxidant activity-guided fractionation of blue wheat (UC66049 Triticum aestivum L.). Journal of Agricultural and Food Chemistry 60(3), 731-739 (2012).
[2]. Zhang, J., Hou, X., Ahmad, H., et al. Assessment of free radicals scavenging activity of seven natural pigments and protective effects in AAPH-challenged chicken erythrocytes. Food Chemistry 145, 57-65 (2014).
[3]. Zikri, N.N., Riedl, K.M., Wang, L.S., et al. Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. Nutrition and Cancer 61(6), 816-826 (2009).
[4]. Santos, J., La, V.D., Bergeron, C., et al. Inhibition of host- and bacteria-derived proteinases by natural anthocyanins. J.Periodontal.Res. 46(5), 550-557 (2011).
[5]. Wu, T., Qi, X., Liu, Y., et al. Dietary supplementation with purified mulberry (Morus australis Poir) anthocyanins suppresses body weight gain in high-fat diet fed C57BL/6 mice. Food Chemistry 141(1), 482-487 (2013).
| Cas No. | 18719-76-1 | SDF | |
| 别名 | 花青素鼠李葡糖苷,Cyanidin 3-rutinoside | ||
| 化学名 | 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-1-benzopyrylium, monochloride | ||
| Canonical SMILES | OC(C(O)=C1)=CC=C1C2=[O+]C3=CC(O)=CC(O)=C3C=C2O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4.[Cl-] | ||
| 分子式 | C27H31O15•Cl | 分子量 | 631 |
| 溶解度 | 20 mg/ml in DMF, 25 mg/ml in DMSO, 1 mg/ml in Ethanol, 2 mg/ml in PBS (pH 7.2): | 储存条件 | Store at -20°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5848 mL | 7.9239 mL | 15.8479 mL |
| 5 mM | 0.317 mL | 1.5848 mL | 3.1696 mL |
| 10 mM | 0.1585 mL | 0.7924 mL | 1.5848 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet