Kumatakenin

Kumatakenin is a flavonoid that has been found in S. aromaticum and has diverse biological activities.^1,2,3 It inhibits the growth of SKOV3 and A2780 ovarian cancer cells in a concentration-dependent manner.¹ It induces apoptosis and decreases the protein levels of the tumor-associated macrophage (TAM) recruitment factors MCP-1 and RANTES in SKOV3 cells when used at a concentration of 30 ?M. Kumatakenin (10 ?M) inhibits neutrophil elastase activity and inhibits antigen-induced RBL-2H3 mast cell degranulation (IC₅₀ = 80.4 ?M).² It is active against S. aureus, E. coli, P. aeruginosa, and L. monocytogenes (MICs = 64, 128, 128, and 512 ?g/ml, respectively) and acts synergistically with ampicillin , gentamicin, or erythromycin to reduce L. monocytogenes biofilm formation.³

1.Woo, J.-H., Ahn, J.-H., Jang, D.S., et al.Effect of kumatakenin isolated from cloves on the apoptosis of cancer cells and the alternative activation of tumor-associated macrophagesJ. Agric. Food Chem.65(36)7893-7899(2017) 2.Ebada, S.S., Al-Jawabri, N.A., Youssef, F.S., et al.Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: Identification, structure–activity relationships, molecular modeling and impact on its folk medicinal usesRSC Adv.10(62)38128-38141(2020) 3.Zhang, X., Wang, L., Mu, H., et al.Synergistic antibacterial effects of Buddleja albiflora metabolites with antibiotics against Listeria monocytogenesLett. Appl. Microbiol.68(1)38-47(2019)