L 601920-0 (Methyl-3β-hydroxycholenate)
(Synonyms: 5-胆烯-24-酸-3Β-醇甲酯) 目录号 : GC32044
L 601920-0 (Methyl-3β-hydroxycholenate) 是一种从专利 US20110263046 A1 中提取的 ROR γ 调节剂，如图 2 所示。
Cas No.:20231-57-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
L 601920-0 is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
[1]. Deuschle, Ulrich, et al. Methods of identification of novel ligands for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (NR1F3) activity. US20110263046A1.
| Cas No. | 20231-57-6 | SDF | |
| 别名 | 5-胆烯-24-酸-3Β-醇甲酯 | ||
| Canonical SMILES | C[C@H](CCC(OC)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C | ||
| 分子式 | C25H40O3 | 分子量 | 388.58 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5735 mL | 12.8674 mL | 25.7347 mL |
| 5 mM | 0.5147 mL | 2.5735 mL | 5.1469 mL |
| 10 mM | 0.2573 mL | 1.2867 mL | 2.5735 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
4-[18F]Fluoro-2-D-methyl-3-mercaptopropanoyl-L-proline
The renin–angiotensin system (RAS) plays a very important role in blood pressure regulation (1-4) in humans. Renin is an enzyme produced in the kidneys and it cleaves circulating angiotensinogen (a protein produced in the liver) to yield angiotensin I, an inactive decapeptide. The angiotensin-converting enzyme (ACE), found primarily in the lung, converts angiotensin I to angiotensin II, an active vasoconstrictor octapeptide. Angiotensin II also stimulates the production of aldosterone from the adrenal glands that promotes sodium and water retention. ACE is also responsible for inactivating bradykinin, a vasodilator (5). RAS and angiotensin II also play a role in interstitial fibrosis, cardiac remodeling and fibrosis, and heart failure (6, 7). It has also been shown that RAS operates in the heart, and the upregulation of this system is related to heart failure (8-10). Inhibition of ACE in patients with heart failure has often resulted in a favorable outcome for the patient (11). In this regard, captopril (2-D-methyl-3-mercaptopropanoyl-L-proline) was developed as an orally active ACE inhibitor and is considered an important drug for the treatment of hypertension. Subsequently, [18F]fluorocaptopril ([18F]FCAP) was developed for use with PET (12) to understand the in vivo dynamics of ACE activity.
Methyldopa
Because of the low levels of methyldopa in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.
Captopril
Because of the low levels of captopril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.
Methyl 3,4-O-isopropyl-idene-2-O-[(methyl-sulfan-yl)thio-carbon-yl]-β-l-arabinoside
In the title compound, C(11)H(18)O(5)S(2), the six- and five-membered rings adopt a chair and an approximately planar conformation, respectively.
Mild Copper-Catalyzed, l-Proline-Promoted Cross-Coupling of Methyl 3-Amino-1-benzothiophene-2-carboxylate
Cu-catalyzed N-arylation is a useful tool for the chemical modification of aromatic heterocycles. Herein, an efficient carbon-nitrogen cross-coupling of methyl 3-amino-1-benzothiophene-2-carboxylate with a range of (hetero)aryl iodides using CuI, l-proline and Cs2CO3 in dioxane at moderate temperature is described. The procedure is an extremely general, relatively cheap, and experimentally simple way to afford the N-substituted products in moderate to high yields. The structures of the new heterocyclic compounds were confirmed by NMR spectroscopy and HRMS investigation.