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L-689502 Sale

目录号 : GC32013

L-689502是一个有效的HIV-1蛋白酶(HIV-lprotease)抑制剂,其IC50值为1nM。

L-689502 Chemical Structure

Cas No.:138483-63-3

规格 价格 库存 购买数量
1mg
¥32,130.00
现货
5mg
¥80,325.00
现货
10mg
¥136,553.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM.

Both L694746 and L-689502 inhibit HIV-l ptotease activity in a concentration-dependent manner. Pepstatin is much less potent than either compound exhibiting an IC50 of 2 μM. L694746 is as potent as L-689502 in inhibiting the HIV-l protease despite being structurally different from L-689502[1].

[1]. Lingham RB, et al. HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1456-61.

实验参考方法

Cell experiment:

G689502 (3.3 pmoles in 1 mL of 100% DMSO) is added to cultures that have been growing for 48 hr. The final substrate and DMSO concentrations during the fermentation period are 65 pM and 2%, respectively. The fermentations containing L-689502 are carried out for an additional 72-96 hr prior to be harvested.The whole broth is sequenthdly extracted with methanol (0.5 vol) and acetone (0.5 vol). The supematant containing the derivatives of L-689502 is separated from the mycelia by filtration[1].

References:

[1]. Lingham RB, et al. HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1456-61.

化学性质

Cas No. 138483-63-3 SDF
Canonical SMILES O=C(OC(C)(C)C)N[C@@H](CC1=CC=CC=C1)[C@@H](O)C[C@@H](CC2=CC=C(OCCN3CCOCC3)C=C2)C(N[C@@H]4[C@H](O)CC5=C4C=CC=C5)=O
分子式 C39H51N3O7 分子量 673.84
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.484 mL 7.4202 mL 14.8403 mL
5 mM 0.2968 mL 1.484 mL 2.9681 mL
10 mM 0.1484 mL 0.742 mL 1.484 mL
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