L-Cysteine-15N-d3
(Synonyms: L-Cys-15N-d3, L-(+)-Cysteine-15N-d3, (R)-Cysteine-15N-d3) 目录号 : GC52283
An internal standard for the quantification of L-cysteine
Cas No.:1795787-05-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
L-Cysteine-15N-d3 is intended for use as an internal standard for the quantification of L-cysteine by GC- or LC-MS. L-Cysteine is a conditionally essential amino acid.1,2 It is produced from L-methionine through the transsulfuration pathway.1 L-Cysteine can also be derived from dietary sources and protein turnover. It is a precursor in the biosynthesis of the intracellular antioxidant glutathione . L-Cysteine supplementation increases GSH levels as well as decreases oxidative stress and pro-inflammatory cytokine levels in various rat and porcine disease models, including type 2 diabetes, aging, and inflammatory bowel disease (IBD). It is also an excitotoxin, inducing neuronal damage by overactivation of NMDA receptors.2
1.Yin, J., Ren, W., Yang, G., et al.L-Cysteine metabolism and its nutritional implicationsMol. Nutr. Food Res.60(1)134-146(2016) 2.JanÁky, R., Varga, V., Hermann, A., et al.Mechanisms of L-cysteine neurotoxicityNeurochem. Res.25(9-10)1397-1405(2000)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 7.9872 mL | 39.9361 mL | 79.8722 mL |
| 5 mM | 1.5974 mL | 7.9872 mL | 15.9744 mL |
| 10 mM | 0.7987 mL | 3.9936 mL | 7.9872 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。