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L-Histidinol (hydrochloride) Sale

(Synonyms: L-组氨醇二盐酸盐,(S)-Histidinol) 目录号 : GC16438

An intermediate in L-histidine biosynthesis

L-Histidinol (hydrochloride) Chemical Structure

Cas No.:1596-64-1

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Sample solution is provided at 25 µL, 10mM.

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产品描述

L-Histidinol is an intermediate in the biosynthesis of the amino acid L-histidine.

L-Histidine biosynthesis is a metabolic pathway present in bacteria, archaea, lower eukaryotes, as well as plants. L-histidine biosynthesis has been studied mainly in Escherichia coli and Salmonella typhimurium, revealing fundamental regulatory processes in bacteria.

In vitro: Preliminary experiments were done to investigate the cytotoxic effect of L-histidinol on cultured EAC cells. Results showed that L-histidinol up to 4 mM had no cytotoxic effects on EAC cells. Doxorubicin alone showed concentration-dependent cytotoxic effects. L-Histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to EAC cells compared to doxorubicin alone. The concentration that caused 50% growth inhibition in EAC cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when L-histidinol was added to culture medium [1].

In vivo: L-Histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in EAC-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. In normal mice, L-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Al-Shabanah OA, Badary OA, Al-Gharably NM, Al-Sawaf HA.  Effects of L-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. Pharmacol Res. 1998 Sep;38(3):225-30.

Chemical Properties

Cas No. 1596-64-1 SDF
别名 L-组氨醇二盐酸盐,(S)-Histidinol
化学名 (βS)-amino-1H-imidazole-5-propanol, dihydrochloride
Canonical SMILES OC[C@@H](N)CC1=CNC=N1.Cl.Cl
分子式 C6H11N3O • 2HCl 分子量 214.1
溶解度 ≤5mg/ml in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 4.6707 mL 23.3536 mL 46.7071 mL
5 mM 0.9341 mL 4.6707 mL 9.3414 mL
10 mM 0.4671 mL 2.3354 mL 4.6707 mL
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