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L-Homopropargyl Glycine

(Synonyms: (S)-2-氨基-5-己炔酸,Click Tag? L-Homopropargyl Glycine,HPG) 目录号 : GC14450

A methionine analog for click chemistry

L-Homopropargyl Glycine Chemical Structure

Cas No.:98891-36-2

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5mg
¥444.00
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10mg
¥698.00
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50mg
¥2,585.00
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100mg
¥3,426.00
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Sample solution is provided at 25 µL, 10mM.

Description

L-homopropargylglycine (Hpg), an alkyne-tagged analog of methionine, has been used to selectively tag newly synthesized mammalian proteins in a method similar to conventional pulse-chase labeling, and labeled proteins were visualized via fluorescence. Protein translation has been implicated in different forms of synaptic plasticity, but direct in situ visualization of new proteins is limited to one or two proteins at a time. Homopropargylglycine is a noncanonical amino acid which can incorporate into proteins followed by chemoselective fluorescence tagging by means of 'click chemistry'. Pulse-chase application of homopropargylglycine allowed visualization of proteins synthesized in two sequential time periods. This technique can be used to detect changes in protein synthesis and to evaluate the fate of proteins synthesized in different cellular compartments [1].

Reference:
[1] Dieterich D C, Hodas J J L, Gouzer G, et al.  In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons[J]. Nature neuroscience, 2010, 13(7): 897-905.

化学性质

Cas No. 98891-36-2 SDF
别名 (S)-2-氨基-5-己炔酸,Click Tag? L-Homopropargyl Glycine,HPG
化学名 (2S)-2-amino-5-hexynoic acid
Canonical SMILES C#CCC[C@H](N)C(O)=O
分子式 C6H9NO2 分子量 127.1
溶解度 ≤10mg/ml in PBS(pH7.2) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 7.8678 mL 39.3391 mL 78.6782 mL
5 mM 1.5736 mL 7.8678 mL 15.7356 mL
10 mM 0.7868 mL 3.9339 mL 7.8678 mL
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