L-Xylose
(Synonyms: L-(-)木糖,L-(-)-Xylose) 目录号 : GC39272
L-Xylose is a synthesized levorotary form of Xylose, a sugar first isolated from wood.
Cas No.:609-06-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
L-Xylose is a synthesized levorotary form of Xylose, a sugar first isolated from wood.
| Cas No. | 609-06-3 | SDF | |
| 别名 | L-(-)木糖,L-(-)-Xylose | ||
| Canonical SMILES | O=C[C@H]([C@@H]([C@H](CO)O)O)O | ||
| 分子式 | C5H10O5 | 分子量 | 150.13 |
| 溶解度 | DMSO : 30mg/mL; Water : 30mg/mL | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.6609 mL | 33.3045 mL | 66.6089 mL |
| 5 mM | 1.3322 mL | 6.6609 mL | 13.3218 mL |
| 10 mM | 0.6661 mL | 3.3304 mL | 6.6609 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[Biocatalysis of formaldehyde to L-Xylose]
Sheng Wu Gong Cheng Xue Bao 2020 May 25;36(5):942-948.PMID:32567277DOI:10.13345/j.cjb.190554.
It is of great significance to use biosynthesis to transform the inorganic substance formaldehyde into organic sugars. Most important in this process was to find a suitable catalyst combination to achieve the dimerization of formaldehyde. In a recent report, an engineered glycolaldehyde synthase was reported to catalyze this reaction. It could be combined with engineered D-fructose-6-phosphate aldolase, a "one-pot enzyme" method, to synthesize L-Xylose using formaldehyde and the conversion rate could reach up to 64%. This process also provides a reference for the synthesis of other sugars. With the increasing consumption of non-renewable resources, it was of great significance to convert formaldehyde into sugar by biosynthesis.
Production of L-Xylose from L-xylulose using Escherichia coli L-fucose isomerase
Enzyme Microb Technol 2012 Jan 5;50(1):71-6.PMID:22133443DOI:10.1016/j.enzmictec.2011.09.009.
L-Xylulose was used as a raw material for the production of L-Xylose with a recombinantly produced Escherichia coli L-fucose isomerase as the catalyst. The enzyme had a very alkaline pH optimum (over 10.5) and displayed Michaelis-Menten kinetics for L-xylulose with a K(m) of 41 mM and a V(max) of 0.23 μmol/(mg min). The half-lives determined for the enzyme at 35 °C and at 45 °C were 6h 50 min and 1h 31 min, respectively. The reaction equilibrium between L-xylulose and L-Xylose was 15:85 at 35 °C and thus favored the formation of L-Xylose. Contrary to the L-rhamnose isomerase catalyzed reaction described previously [14]L-lyxose was not detected in the reaction mixture with L-fucose isomerase. Although xylitol acted as an inhibitor of the reaction, even at a high ratio of xylitol to L-xylulose the inhibition did not reach 50%.
Effects of insulin on the permeability of D- and L-Xylose and D- and L-arabinose in rat diaphragm muscle
J Gen Physiol 1961 Nov;45(2):309-16.PMID:13876608DOI:10.1085/jgp.45.2.309.
The permeability characteristics of D- and L-Xylose and D- and L-arabinose have been compared in isolated intact rat diaphragm muscle preparations, in the absence and presence of exogenous insulin. In the absence of added insulin, these pentoses distribute in less than a third of the total cell water. In the presence of added insulin, intracellular distribution of all these pentoses is increased. L-Xylose and D-arabinose distribute in 50 per cent of the intracellular water, whereas D-xylose and L-arabinose distribute in 80 per cent of the cell water. A significant lag period was observed before the insulin effect upon the penetration of L-Xylose and D-arabinose was evident whereas the effect upon D-xylose and L-arabinose was rapid. The lag period with L-Xylose could be abolished by pretreating the tissues with insulin for 1 hour, but such pretreatment had little effect on D-xylose. These results indicate that insulin has a biphasic effect upon the monosaccharide exclusion system in diaphragm muscle. In dinitrophenol-treated tissues, in which all permeability processes are irreversibly damaged and in which sucrose and pentoses penetrate into most of the cell water, the entry rate of pentoses and sucrose is initially similar but subsequently D-xylose and L-arabinose penetrate more rapidly than their corresponding optical isomers.
Control of Crystallinity and Stereocomplexation of Synthetic Carbohydrate Polymers from d- and L-Xylose
Angew Chem Int Ed Engl 2021 Feb 23;60(9):4524-4528.PMID:33225519DOI:10.1002/anie.202013562.
Manipulating the stereochemistry of polymers is a powerful method to alter their physical properties. Despite the chirality of monosaccharides, reports on the impact of stereochemistry in natural polysaccharides and synthetic carbohydrate polymers remain absent. Herein, we report the cocrystallisation of regio- and stereoregular polyethers derived from d- and L-Xylose, leading to enhanced thermal properties compared to the enantiopure polymers. To the best of our knowledge, this is the first example of a stereocomplex between carbohydrate polymers of opposite chirality. In contrast, atactic polymers obtained from a racemic mixture of monomers are amorphous. We also show that the polymer hydroxyl groups are amenable to post-polymerisation functionalization. These strategies afford a family of carbohydrate polyethers, the physical and chemical properties of which can both be controlled, and which opens new possibilities for polysaccharide mimics in biomedical applications or as advanced materials.
Advances in applications, metabolism, and biotechnological production of L-xylulose
Appl Microbiol Biotechnol 2016 Jan;100(2):535-40.PMID:26526452DOI:10.1007/s00253-015-7087-y.
L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of α-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-Xylose which contribute to the production of antiviral drugs. Chemical synthesis of L-xylulose was performed, but it is difficult and low yielding. The biotransformation from xylitol to L-xylulose by xylitol 4-dehydrogenase was studied intensively. This review describes the occurrence of L-xylulose in certain metabolic pathways, its bioproduction, and application potential.