Ladostigil hydrochloride

(Synonyms: TV-3326 hydrochloride) 目录号 : GC69353

Ladostigil (TV-3326) hydrochloride 是一种口服有效的胆碱酯酶 (cholinesterase) 和脑选择性单胺氧化酶 (MAO) 的双重抑制剂，抑制 MAO-B 和 AChE 的 IC50 值分别为 37.1 和 31.8 μM。Ladostigil hydrochloride 具有神经保护，抗氧化和抗炎的作用，可用于抑郁症和阿尔茨海默症的研究。

Cas No.:209394-18-3

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Sample solution is provided at 25 µL, 10mM.

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Description

Ladostigil (TV-3326) drochloride is an orally active dual inhibitor of Inhibited brain MAO-A and B by more than 60%.
Reduced peranxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.

[1]. Denya I, et, al. Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease. Medchemcomm. 2018 Jan 16; 9(2):357-370.
[2]. Weinreb O, et, al. Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr; 13(4): 483-94.
[3]. Weinstock M, et, al. Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression. J Neural Transm Suppl. 2006; (70):443-6.
[4]. Poltyrev T, et, al. Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the pothalamic-pituitary-adrenal axis in male and female prenatally stressed rats. Psychopharmacology (Berl). 2005 Aug;181(1): 118-25.