Lanolin
(Synonyms: 绵羊油) 目录号 : GC39122
Lanolin (wool wax, wool grease) is a wax secreted by the sebaceous glands of wool-bearing animals and used widely in the pharmaceutical and cosmetics industries.
Cas No.:8006-54-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Lanolin (wool wax, wool grease) is a wax secreted by the sebaceous glands of wool-bearing animals and used widely in the pharmaceutical and cosmetics industries.
| Cas No. | 8006-54-0 | SDF | |
| 别名 | 绵羊油 | ||
| Canonical SMILES | [Lanolin] | ||
| 分子式 | C54H84N16O21 | 分子量 | 1293.34 |
| 溶解度 | DMSO : 100mg/mL | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.7732 mL | 3.866 mL | 7.7319 mL |
| 5 mM | 0.1546 mL | 0.7732 mL | 1.5464 mL |
| 10 mM | 0.0773 mL | 0.3866 mL | 0.7732 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The Lanolin paradox
Dermatology 1996;192(3):198-202.PMID:8726630DOI:10.1159/000246365.
Several puzzling aspects of the use of Lanolin are discussed as "Lanolin paradoxes', in analogy with the 'paraben paradoxes'. Lanolin in topical therapeutic agents sensitizes a high proportion of patients, whereas the same Lanolin is 'safe' in cosmetics so widely used by millions of individuals. Patients with an allergic contact dermatitis to Lanolin in a medication applied to a stasis ulcer can nevertheless use lanolin-containing cosmetics and not experience a reaction. Lanolin-sensitive individuals often show false-negative patch test reactions to unaltered Lanolin. Patch testing with 30% wool wax alcohols used in the standard patch test tray cannot be considered a reliable method for detecting and confirming Lanolin allergies. There are too many false-positive and false-negative results using the standard patch test tray.
Lanolin
Dermatitis 2023 Jan-Feb;34(1):4-12.PMID:36917502DOI:10.1089/derm.2022.0002.
Lanolin is a complex mixture of high molecular weight esters, aliphatic alcohols, sterols, fatty acids, and hydrocarbons that has been widely used for centuries for its emollient properties. The purification of crude Lanolin into Lanolin wax and the processing of this wax into various derivatives began in 1882 and continue to this day with newer highly purified anhydrous lanolins. Controversy as to Lanolin's allergenicity began in the 1920s and remains an issue. The most appropriate patch test preparation(s) for detecting allergy remain disputed. Detection of lanolin-induced contact dermatitis in diseased skin by patch testing on normal skin may lead to false negative results. Patients with a positive patch test to Lanolin may tolerate use of Lanolin on normal skin. Although Lanolin is a weak sensitizer and the frequency of contact allergy to it in the European population reportedly is 0.4%, there are high-risk concomitant conditions: stasis dermatitis, leg ulcers, perianal/genital dermatitis, and atopic dermatitis (AD). Children and the elderly are also at greater risk of developing contact allergy to Lanolin, partly because of comorbidities (AD and stasis dermatitis/leg ulcers, respectively). Finally, in the United States, non-Hispanic white patients are more likely than their non-Hispanic black counterparts to be Lanolin allergic.
Lanolin for the treatment of nipple pain in breastfeeding women: a randomized controlled trial
Matern Child Nutr 2017 Jul;13(3):e12357.PMID:27477840DOI:10.1111/mcn.12357.
Nipple pain and damage are commonly experienced by breastfeeding women and are associated with negative breastfeeding outcomes. Health care providers often recommend the application of Lanolin to treat painful/damaged nipples, yet no randomized controlled trial has evaluated the effectiveness of Lanolin on nipple pain and breastfeeding outcomes. The purpose of this study was to evaluate the effect of Lanolin on nipple pain among breastfeeding women with damaged nipples. A randomized, single-blind, controlled trial was conducted at a tertiary care hospital in Hamilton, Ontario, Canada. Breastfeeding women (N = 186) identified as having nipple pain/damage were randomized to apply Lanolin (intervention group; n = 93) or to receive usual postpartum care (control group; n = 93). The primary outcome was nipple pain at 4 days post-randomization measured by the Numeric Rating Scale. Additional outcomes included nipple pain measured by the Short Form McGill Pain Questionnaire, breastfeeding duration/exclusivity, breastfeeding self-efficacy, and maternal satisfaction with Lanolin treatment versus usual care. The results revealed no significant group differences in mean pain scores at 4 days post-randomization. Women in both groups experienced clinically relevant decreases in nipple pain by 7 days post-randomization. Significantly, more women in the Lanolin group reported that they were satisfied with treatment compared with those receiving usual care. No significant group differences were found for other secondary outcomes. While more women were satisfied using Lanolin, its application to sore/damaged nipples was ineffective for reducing nipple pain or improving breastfeeding outcomes.
Lanolin allergy: history, epidemiology, responsible allergens, and management
Dermatitis 2008 Mar-Apr;19(2):63-72.PMID:18413106doi
Allergy to Lanolin has been recognized by dermatologists for decades. This review summarizes the history, epidemiology, and allergenicity of Lanolin and its derivatives. "The Lanolin paradox" and the safety of pharmaceutical-grade Lanolin products are also discussed.
Lanolin Allergic Reactions: North American Contact Dermatitis Group Experience, 2001 to 2018
Dermatitis 2022 May-Jun;33(3):193-199.PMID:35481824DOI:10.1097/DER.0000000000000871.
Background: Lanolin is an important cause of allergic contact dermatitis. Objectives: The aims of this study were to describe the epidemiology of Lanolin allergy and to assess trends in patch test reactions to Lanolin over time. Methods: This study used a retrospective analysis of patients patch tested with Lanolin alcohol 30% or Amerchol L-101 50% in petrolatum by the North American Contact Dermatitis Group between 2001 and 2018 (n = 43,691). Results: Overall, 1431 (3.3%) had a positive reaction, and 1238 (2.8%) were currently relevant. Prevalence of Lanolin allergy was 4.63% between 2011 and 2018 (P < 0.0001). Most lanolin-allergic patients had + (52%) reactions; 18%, and 6% had ++ and +++ reactions, respectively. Common primary anatomic sites of dermatitis were the hands (20.7%), scattered/generalized distribution (19.6%), and face (17.0%). Allergic reactions to Lanolin were more common in children (4.5%) than in adults (3.2%, P = 0.0018). Compared with nonallergic patients, lanolin-allergic patients were more likely to have history of eczema or hay fever, male sex, older than 40 years, or Black race (P < 0.05). Common Lanolin sources were personal care products and drugs/medications. Only 2.24% of the positive reactions were linked to occupation. Conclusions: Lanolin sensitivity was common. Reactions were often clinically relevant and linked to personal care products and medications.