Lapachol
(Synonyms: 拉帕醇) 目录号 : GC39123
A naphthoquinone with diverse biological activities
Cas No.:84-79-7
Sample solution is provided at 25 µL, 10mM.
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Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.1,2,3,4,5 It is larvicidal against T. canis when used at a concentration of 2 mg/ml.1 Lapachol (10 and 100 ?M) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells.2 It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 ?g/ml.3 Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis.4 It also reduces carrageenan-induced paw edema and abscess formation in rats.5
1.Mata-Santos, T., Pinto, N.F., Mata-Santos, H.A., et al.Anthelmintic activity of lapachol, β-lapachone and its derivatives against Toxocara canis larvaeRev. Inst. Med. Trop. Sao Paulo57(3)197-204(2015) 2.Xu, H., Chen, Q., Wang, H., et al.Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase IIJ. Exp. Clin. Cancer Res.35(1)178(2016) 3.Strauch, M.A., Tomaz, M.A., Monteiro-Machado, M., et al.Lapachol and synthetic derivatives: In vitro and in vivo activities against Bothrops snake venomsPLoS One14(1)(2019) 4.Peres, R.S., Santos, G.B., Cecilio, N.T., et al.Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritisArthritis Res. Ther.19(1)47(2017) 5.de Almeida, E.R., da Silva Filho, A.A., do Santos, E.R., et al.Antiinflammatory action of lapacholJ. Ethnopharmacol.29(2)239-241(1990)
| Cas No. | 84-79-7 | SDF | |
| 别名 | 拉帕醇 | ||
| Canonical SMILES | O=C(C(CC=C(C)C)=C1O)C2=CC=CC=C2C1=O | ||
| 分子式 | C15H14O3 | 分子量 | 242.27 |
| 溶解度 | DMSO: ≥ 100 mg/mL (412.76 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.1276 mL | 20.6381 mL | 41.2763 mL |
| 5 mM | 0.8255 mL | 4.1276 mL | 8.2553 mL |
| 10 mM | 0.4128 mL | 2.0638 mL | 4.1276 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet