Lasalocid
(Synonyms: 那塞罗; Lasalocid-A; Ionophore X-537A; Antibiotic X-537A) 目录号 : GC17768
An ionophore antibiotic
Cas No.:25999-31-9
Sample solution is provided at 25 µL, 10mM.
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Lasalocid is an ionophore antibiotic.
Lasalocid is produced by Streptomyces lasaliensis and is a mixture of several closely related homologue substances A, B, C, D, E. The sum of the lasalocid homologues B, C, D, E is limited to 10% of the total weight of the active substance, lasalocid.
In vitro: A previous study was conducted to compare effects of the combined use of lasalocid and silybin in chicken hepatoma cells and rat myoblasts cell lines cultures. Results showed that in all performed tests, the lowest lasalocid EC50-values were obtained for chicken hepatocytes. In the rat myoblasts cultures, the lowest lasalocid EC50-values were found. Moreover, a lack of silybin cytotoxic effect was proven for the studied cell lines. An interaction between both substances resulted in a great decrease of lasalocid cytotoxicity. The isobolograms and combination index indicated a significant antagonistic nature of silybin effect in the course of lasalocid cytotoxicity [1].
In vivo: In a animal study, chickens 8 or 9 days old were given a completely purified crystalline amino acid diet. Results showed that the requirement for sulphur-containing amino acids (SAA) was neither increased nor decreased by lasalocid at 125 mg/kg diet. Moreover, lasalocid could cause a significant increase in gain and gain/feed intake when added to diets that were deficient in SAA, but it led to a marked decrease in performance when added to diets adequate in SAA. In addition, at moderate levels of SAA deficiency, lasalocid at 125 mg/kg could neither increase nor decrease the rate and efficiency of weight gain and there was no evidence of the SAA X lasalocid interaction when lasalocid was given in a typical starter diet of maize and soya [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Radko, L. ,Cybulski, W., and Rzeski, W. The protective effect of silybin against lasalocid cytotoxic exposure on chicken and rat cell lines. Biomed.Res.Int. 2013, 1-8 (2013).
[2] Willis GM, Baker DH. Lasalocid-sulfur amino acid interrelationship in the chick. Poult Sci. 1980 Nov;59(11):2538-43.
| Cas No. | 25999-31-9 | SDF | |
| 别名 | 那塞罗; Lasalocid-A; Ionophore X-537A; Antibiotic X-537A | ||
| 化学名 | 6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]tetrahydro-3-methyl-2-furanyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methyl-benzoic acid | ||
| Canonical SMILES | OC(C1=C(CC[C@@H](C)[C@H](O)[C@H](C)C([C@@H]([C@]2([H])[C@@H](C)C[C@]([C@]3([H])O[C@@H](C)[C@@](O)(CC)CC3)(CC)O2)CC)=O)C=CC(C)=C1O)=O | ||
| 分子式 | C34H54O8 | 分子量 | 590.8 |
| 溶解度 | DMSO : 100 mg/mL (169.26 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6926 mL | 8.4631 mL | 16.9262 mL |
| 5 mM | 0.3385 mL | 1.6926 mL | 3.3852 mL |
| 10 mM | 0.1693 mL | 0.8463 mL | 1.6926 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >96.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet