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Lasalocid Sale

(Synonyms: 那塞罗; Lasalocid-A; Ionophore X-537A; Antibiotic X-537A) 目录号 : GC17768

An ionophore antibiotic

Lasalocid Chemical Structure

Cas No.:25999-31-9

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5mg
¥540.00
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10mg
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25mg
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50mg
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100mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Lasalocid is an ionophore antibiotic.

Lasalocid is produced by Streptomyces lasaliensis and is a mixture of several closely related homologue substances A, B, C, D, E. The sum of the lasalocid homologues B, C, D, E is limited to 10% of the total weight of the active substance, lasalocid.

In vitro: A previous study was conducted to compare effects of the combined use of lasalocid and silybin in chicken hepatoma cells and rat myoblasts cell lines cultures. Results showed that in all performed tests, the lowest lasalocid EC50-values were obtained for chicken hepatocytes. In the rat myoblasts cultures, the lowest lasalocid EC50-values were found. Moreover, a lack of silybin cytotoxic effect was proven for the studied cell lines. An interaction between both substances resulted in a great decrease of lasalocid cytotoxicity. The isobolograms and combination index indicated a significant antagonistic nature of silybin effect in the course of lasalocid cytotoxicity [1].

In vivo: In a animal study, chickens 8 or 9 days old were given a completely purified crystalline amino acid diet. Results showed that the requirement for sulphur-containing amino acids (SAA) was neither increased nor decreased by lasalocid at 125 mg/kg diet. Moreover, lasalocid could cause a significant increase in gain and gain/feed intake when added to diets that were deficient in SAA, but it led to a marked decrease in performance when added to diets adequate in SAA. In addition, at moderate levels of SAA deficiency, lasalocid at 125 mg/kg could neither increase nor decrease the rate and efficiency of weight gain and there was no evidence of the SAA X lasalocid interaction when lasalocid was given in a typical starter diet of maize and soya [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Radko, L. ,Cybulski, W., and Rzeski, W. The protective effect of silybin against lasalocid cytotoxic exposure on chicken and rat cell lines. Biomed.Res.Int. 2013, 1-8 (2013).
[2] Willis GM, Baker DH. Lasalocid-sulfur amino acid interrelationship in the chick. Poult Sci. 1980 Nov;59(11):2538-43.

Chemical Properties

Cas No. 25999-31-9 SDF
别名 那塞罗; Lasalocid-A; Ionophore X-537A; Antibiotic X-537A
化学名 6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]tetrahydro-3-methyl-2-furanyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methyl-benzoic acid
Canonical SMILES OC(C1=C(CC[C@@H](C)[C@H](O)[C@H](C)C([C@@H]([C@]2([H])[C@@H](C)C[C@]([C@]3([H])O[C@@H](C)[C@@](O)(CC)CC3)(CC)O2)CC)=O)C=CC(C)=C1O)=O
分子式 C34H54O8 分子量 590.8
溶解度 DMSO : 100 mg/mL (169.26 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.6926 mL 8.4631 mL 16.9262 mL
5 mM 0.3385 mL 1.6926 mL 3.3852 mL
10 mM 0.1693 mL 0.8463 mL 1.6926 mL
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