Lauroyl-L-carnitine-12,12,12-d3 (chloride)
(Synonyms: CAR 12:0-d3, C12:0 Carnitine-d3, L-Carnitine lauroyl ester-d3, L-Lauroylcarnitine-d3) 目录号 : GC47546
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Lauroyl-L-carnitine-12,12,12-d3 is intended for use as an internal standard for the quantification of lauroyl-L-carnitine by LC- or GC-MS. Lauroyl-L-carnitine is an acylcarnitine and a surfactant.1 It has been used to permeabilize porcine enterocytes for delivery of the polar fluorescent probe lucifer yellow .
1.Danielsen, E.M., and Hansen, G.H.Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant systemTissue Barriers5(3)e1361900(2017)
| Cas No. | N/A | SDF | |
| 别名 | CAR 12:0-d3, C12:0 Carnitine-d3, L-Carnitine lauroyl ester-d3, L-Lauroylcarnitine-d3 | ||
| Canonical SMILES | C[N+](C)(C)C[C@H](OC(CCCCCCCCCCC([2H])([2H])[2H])=O)CC(O)=O.[Cl-] | ||
| 分子式 | C19H35D3NO4.Cl | 分子量 | 383 |
| 溶解度 | Methanol: slightly soluble,Water: slightly soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.611 mL | 13.0548 mL | 26.1097 mL |
| 5 mM | 0.5222 mL | 2.611 mL | 5.2219 mL |
| 10 mM | 0.2611 mL | 1.3055 mL | 2.611 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The hidden hand of chloride in hypertension
Pflugers Arch 2015 Mar;467(3):595-603.PMID:25619794DOI:10.1007/s00424-015-1690-8.
Among the environmental factors that affect blood pressure, dietary sodium chloride has been studied the most, and there is general consensus that increased sodium chloride intake increases blood pressure. There is accruing evidence that chloride may have a role in blood pressure regulation which may perhaps be even more important than that of Na(+). Though more than 85 % of Na(+) is consumed as sodium chloride, there is evidence that Na(+) and Cl(-) concentrations do not go necessarily hand in hand since they may originate from different sources. Hence, elucidating the role of Cl(-) as an independent player in blood pressure regulation will have clinical and public health implications in addition to advancing our understanding of electrolyte-mediated blood pressure regulation. In this review, we describe the evidence that support an independent role for Cl(-) on hypertension and cardiovascular health.
chloride: not simply a 'cheap osmoticum', but a beneficial plant macronutrient
J Exp Bot 2017 Jun 1;68(12):3057-3069.PMID:28379459DOI:10.1093/jxb/erx050.
At macronutrient levels, chloride has positive effects on plant growth, which are distinct from its function in photosynthesis..
The Influence of the Halide in the Crystal Structures of 1-(2,3,5,6-Tetrafluoro-4-pyridyl)-3-benzylimidazolium Halides
Molecules 2022 Nov 7;27(21):7634.PMID:36364461DOI:10.3390/molecules27217634.
The crystal structures of 1-(2,3,5,6-tetrafluoro-4-pyridyl)-3-benzylimidazolium chloride (1) and iodide (3) have been determined by single crystal X-ray diffraction. The crystal structure of 1 is similar to that of the bromide salt (2), possessing anion···C5F5N···C6H5 motifs, whilst that of 3 contains columns of alternating iodide anions and parallel tetrafluoropyridyl rings. All three crystal structures possess C(1)−H∙∙∙X− and C(2)−H∙∙∙X− hydrogen bonding. DFT calculations reveal that the strengths of the hydrogen bonding interactions lie in the order C(1)−H···X− > C(3)−H···X− > C(2)−H···X− for the same halide (X−) and Cl− > Br− > I− for each position. It is suggested that salt 3 adopts a different structure to salts 1 and 2 because of the larger size of iodide.
chloride cotransporters, chloride homeostasis, and synaptic inhibition in the developing auditory system
Hear Res 2011 Sep;279(1-2):96-110.PMID:21683130DOI:10.1016/j.heares.2011.05.012.
The role of glycine and GABA as inhibitory neurotransmitters in the adult vertebrate nervous system has been well characterized in a variety of model systems, including the auditory, which is particularly well suited for analyzing inhibitory neurotransmission. However, a full understanding of glycinergic and GABAergic transmission requires profound knowledge of how the precise organization of such synapses emerges. Likewise, the role of glycinergic and GABAergic signaling during development, including the dynamic changes in regulation of cytosolic chloride via chloride cotransporters, needs to be thoroughly understood. Recent literature has elucidated the developmental expression of many of the molecular components that comprise the inhibitory synaptic phenotype. An equally important focus of research has revealed the critical role of glycinergic and GABAergic signaling in sculpting different developmental aspects in the auditory system. This review examines the current literature detailing the expression patterns and function (chapter 1), as well as the regulation and pharmacology of chloride cotransporters (chapter 2). Of particular importance is the ontogeny of glycinergic and GABAergic transmission (chapter 3). The review also surveys the recent work on the signaling role of these two major inhibitory neurotransmitters in the developing auditory system (chapter 4) and concludes with an overview of areas for further research (chapter 5).
Dietary chloride Deficiency Syndrome: Pathophysiology, History, and Systematic Literature Review
Nutrients 2020 Nov 9;12(11):3436.PMID:33182508DOI:10.3390/nu12113436.
Metabolic alkalosis may develop as a consequence of urinary chloride (and sodium) wasting, excessive loss of salt in the sweat, or intestinal chloride wasting, among other causes. There is also a likely underrecognized association between poor salt intake and the mentioned electrolyte and acid-base abnormality. In patients with excessive loss of salt in the sweat or poor salt intake, the maintenance of metabolic alkalosis is crucially modulated by the chloride-bicarbonate exchanger pendrin located on the renal tubular membrane of type B intercalated cells. In the late 1970s, recommendations were made to decrease the salt content of foods as part of an effort to minimize the tendency towards systemic hypertension. Hence, the baby food industry decided to remove added salt from formula milk. Some weeks later, approximately 200 infants (fed exclusively with formula milks with a chloride content of only 2-4 mmol/L), were admitted with failure to thrive, constipation, food refusal, muscular weakness, and delayed psychomotor development. The laboratory work-up disclosed metabolic alkalosis, hypokalemia, hypochloremia, and a reduced urinary chloride excretion. In all cases, both the clinical and the laboratory features remitted in ≤7 days when the infants were fed on formula milk with a normal chloride content. Since 1982, 13 further publications reported additional cases of dietary chloride depletion. It is therefore concluded that the dietary intake of chloride, which was previously considered a "mendicant" ion, plays a crucial role in acid-base and salt balance.