Lauroyl-L-carnitine (chloride)
(Synonyms: L-氯化月桂酰肉碱) 目录号 : GC44044
月桂基-l-肉碱是一种天然存在的化合物，属于酰基肉碱家族。
Cas No.:6919-91-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Lauryl-l-carnitine is a naturally occurring compound belonging to the acylcarnitine family. It has been reported that it can be used as a biomarker in the diagnosis of carnitine deficiency.
Lauryl-l-carnitine can be used as a standard for the determination of analytes in maize plants by high performance liquid chromatography-triple quadrupole-liquid chromatography-tandem mass spectrometry (LC-MS/MS). Exogenous application of carnitine stimulates fatty acid transport to mitochondria The possible effects of carnitine on lipid transport between cytoplasmic mitochondrial matrix and mitochondrial respiration in maize leaves grown under normal and cold conditions were investigated[1].
Lauryl-l-carnitine can be used as an analytical standard for quantification of analytes in human urine samples by liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) [2].
References:
[1]: Turk H, Erdal S, Dumlupinar R. Exogenous carnitine application augments transport of fatty acids into mitochondria and stimulates mitochondrial respiration in maize seedlings grown under normal and cold conditions. Cryobiology. 2019 Dec;91:97-103. doi: 10.1016/j.cryobiol.2019.10.003. Epub 2019 Oct 4. PMID: 31589831.
[2]: Abe K, Suzuki H, Maekawa M, Shimada M, Yamaguchi H, Mano N. Matrix effect-corrected liquid chromatography/tandem mass-spectrometric method for determining acylcarnitines in human urine. Clin Chim Acta. 2017 May;468:187-194. doi: 10.1016/j.cca.2017.03.001. Epub 2017 Mar 6. PMID: 28274611.
月桂基-l-肉碱是一种天然存在的化合物,属于酰基肉碱家族。有报道可作为诊断肉毒碱缺乏症的生物标志物。
月桂基-L-肉碱可用作通过高效液相色谱-三重四极杆-液相色谱-串联质谱法 (LC-MS/MS) 测定玉米植物中分析物的标准品。肉毒碱外源促进脂肪酸向线粒体转运研究了肉毒碱对正常和低温条件下生长的玉米叶片细胞质线粒体基质之间脂质转运和线粒体呼吸的可能影响[1]。
月桂基-L-肉碱可用作液相色谱/电喷雾电离串联质谱法 (LC/ESI-MS/MS) 定量分析人尿样分析物的分析标准品[2].
| Cas No. | 6919-91-1 | SDF | |
| 别名 | L-氯化月桂酰肉碱 | ||
| Canonical SMILES | OC(C[C@H](C[N+](C)(C)C)OC(CCCCCCCCCCC)=O)=O.[Cl-] | ||
| 分子式 | C19H38NO4•Cl | 分子量 | 380 |
| 溶解度 | DMSO : 50 mg/mL (131.59 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6316 mL | 13.1579 mL | 26.3158 mL |
| 5 mM | 0.5263 mL | 2.6316 mL | 5.2632 mL |
| 10 mM | 0.2632 mL | 1.3158 mL | 2.6316 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Nasal absorption kinetic behavior of azetirelin and its enhancement by acylcarnitines in rats
Pharm Res 1998 Jan;15(1):77-81.PMID:9487550DOI:10.1023/a:1011952804479.
Purpose: The long-term stability and nasal absorption characteristics of a basic nasal formulation of azetirelin, a thyrotropin-releasing hormone analog and its absorption enhancement by incorporation of acylcarnitines in the formulation were investigated. Methods: The long-term stability of basic nasal azetirelin formulations at 25 degrees C was predicted by calculation from the Arrhenius plot of the data on 6 months' storage at 40, 50 and 60 degrees C. Nasal azetirelin absorption characteristics were kinetically examined by intranasal administration to rats, determination of plasma azetirelin level by radioimmunoassay, and fitting the data to a two-compartment model including absorption rate. Results: Basic nasal azetirelin formulations of pH 4.0 and pH 5.1 were predicted to be highly stable. Residual azetirelin after 2 years storage at 25 degrees C was greater than 95%. Nasal absorption characteristics of this formulation in the pH 4.0-6.3 range showed pH-dependency, with pH 4.0 showing the highest absolute bioavailability (Bioav) of 17.1%. This nasal Bioav was 21 times greater than that of oral administration (0.8%). Acylcarnitines with 12 or more carbon atoms in the acyl chain greatly enhanced nasal absorption of azetirelin: Bioavs with lauroylcarnitine chloride (LCC) and palmitoylcarnitine chloride were 96.9% and 72.9%, respectively. This enhancement by LCC plateaued at the low concentration of 0.1%. Conclusions: The basic nasal azetirelin formulation at pH 4.0 is stable and shows adequate absorption, with nasal absorption having greater Bioav than oral absorption. The 12-carbon acylate LCC was the strongest enhancer among acylcarnitines and provided near-total delivery of the administered dose to the blood.
Enhancement of nasal salmon calcitonin absorption by lauroylcarnitine chloride in rats
Pharm Res 1996 May;13(5):739-43.PMID:8860430DOI:10.1023/a:1016051600828.
Purpose: We investigated optimum formulation characteristics in the nasal absorption of salmon calcitonin (sCT) by incorporation of acylcarnitines. Methods: Nasal sCT formulations were administered to anesthetized rats. Plasma calcium level was measured and pharmacological bioavailability (P.bioav) was calculated. Results: Nasal sCT absorption was significantly enhanced by carnitines with acyl groups of 12 or more carbon atoms. Enhancement by lauroylcarnitine chloride (LCC) was observed at its critical micelle concentration and reached a plateau at the concentration of 0.1 percent. Optimal absorption was achieved at a molar ratio of LCC to sCT of 5:1. Enhancement was not influenced by osmolarity and maximum enhancement was obtained at pHs 3.1 and 4.0. Conclusions: The 12-carbon LCC was the strongest enhancer among acylcarnitines. Micelle formation played a key role in this enhancement effect.