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Leflunomide-d4 Sale

(Synonyms: 来氟米特 d4) 目录号 : GC47552

An internal standard for the quantification of leflunomide

Leflunomide-d4 Chemical Structure

Cas No.:1189987-23-2

规格 价格 库存 购买数量
500 μg
¥2,552.00
现货
1 mg
¥4,334.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Leflunomide-d4 is intended for use as an internal standard for the quantification of leflunomide by GC- or LC-MS. Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 , a dihydroorotate dehydrogenase inhibitor.1 Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of 25 and 100 µM, respectively, for naÏve and memory CD4+ T cells.2 It also reduces the production of Th1 effector cells and increases differentiation of Th2 cells in vitro and in splenocytes isolated from KLH-immunized mice. Leflunomide (35 mg/kg per day) reduces and prevents inflammation in a proteoglycan-induced mouse model of rheumatoid arthritis.3 Formulations containing leflunomide have been used in the treatment of active rheumatoid arthritis.

1.Breedveld, F.C., and Dayer, J.-M.Leflunomide: Mode of action in the treatment of rheumatoid arthritisAnn. Rheum. Dis.59(11)841-849(2000) 2.Dimitrova, P., Skapenko, A., Herrmann, M.L., et al.Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiationJ. Immunol.169(6)3392-3399(2002) 3.Glant, T.T., Mikecz, K., Bartlett, R.R., et al.Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomideImmunopharmacology23(2)105-116(1992)

化学性质

Cas No. 1189987-23-2 SDF
别名 来氟米特 d4
Canonical SMILES O=C(C1=C(C)ON=C1)NC2=C([2H])C([2H])=C(C(F)(F)F)C([2H])=C2[2H]
分子式 C12H5D4F3N2O2 分子量 274.2
溶解度 DMSO: soluble,Methanol: soluble 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.647 mL 18.2349 mL 36.4697 mL
5 mM 0.7294 mL 3.647 mL 7.2939 mL
10 mM 0.3647 mL 1.8235 mL 3.647 mL
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