Leptin Receptor Human
目录号 : GP20716Leptin Binding Domain Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 99.0% as determined by:(a)Gel filtration analysis.(b) Analysis by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | OB Protein; Obesity Protein; OBS; Obesity factor; Leptin Receptor. | ||
| Amino Acid Sequence | The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Ile-Asp-Val-Asn-Ile. | ||
| Solubility | It is recommended to reconstitute the lyophilized Leptin Receptor in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized Leptin Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution Leptin Receptor should be stored at 4°C between 2-7 days and for future use below -18°C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | ||
| Biological Activity | Biological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio. | ||
| Formulation | The protein was lyophilized from a concentrated (0.2-0.5mg/ml) solution of Tris-HCl buffer, pH 9.0 with 150 mM NaCl and 10-fold (w/w) excess of glycine. | ||
Leptin Receptor is a part of the gp130 family of cytokine receptors that stimulate gene transcription by activating cytosolic STAT proteins. Leptin Receptor plays a role in the regulation of fat metabolism and in novel hematopoietic pathway that is obligatory for normal lymphopoiesis. Leptin Receptorparticipates in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus.Leptin Receptoraffectsspecifically on T lymphocyte responses.
Biological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio.
Lyophilized Leptin Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution Leptin Receptor should be stored at 4°C between 2-7 days and for future use below -18°C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.