LGMN Human
目录号 : GP21879Legumain Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Sf9, Baculovirus cells. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Legumain; PRSC1; Protease; Cysteine; 1 (Legumain); Asparaginyl Endopeptidase; Protease; Cysteine 1; EC 3.4.22.34; Cysteine Protease 1; LGMN1; AEP. | ||
| Amino Acid Sequence | VPIDDPEDGG KHWVVIVAGS NGWYNYRHQA DACHAYQIIH RNGIPDEQIV VMMYDDIAYS EDNPTPGIVI NRPNGTDVYQ GVPKDYTGED VTPQNFLAVL RGDAEAVKGI GSGKVLKSGP QDHVFIYFTD HGSTGILVFP NEDLHVKDLN ETIHYMYKHK MYRKMVFYIE ACESGSMMNH LPDNINVYAT TAANPRESSY ACYYDEKRST YLGDWYSVNW MEDSDVEDLT KETLHKQYHL VKSHTNTSHV MQYGNKTIST MKVMQFQGMK RKASSPVPLP PVTHLDLTPS PDVPLTIMKR KLMNTNDLEE SRQLTEEIQR HLDARHLIEK SVRKIVSLLA ASEAEVEQLL SERAPLTGHS CYPEALLHFR THCFNWHSPT YEYALRHLYV LVNLCEKPYP LHRIKLSMDH VCLGHYHHHH HH. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | LGMN protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. | ||
Legumain, also known as LGMN, is a cysteine endopeptidase whichdemonstrates strict specificity for hydrolysis of asparaginyl bonds.Furthermore, LGMN can also cleave aspartyl bonds slowly, in particular underacidic conditions. LGMN plays an essential role in the endosomal/lysosomaldegradation system as the Legumain deficiency causes the accumulation of procathepsins B, H & L, another group of lysosomal cysteine proteases.Furthermore, over expression of LGMN in tumors is important for invasion/metastasis.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.