LMTK3 Inhibitor C28
(Synonyms: Lemur Tyrosine Kinase 3-IN-1; Lemur Tyrosine Kinase-IN-C28; Lemur Tyrosine Kinase 3 Inhibitor 1; Lemur Tyrosine Kinase Inhibitor C28; LMTK3-IN-1; LMTK3-IN-C28; LMTK3 Inhibitor 1) 目录号 : GC91967LMTK3 Inhibitor C28是一种多激酶抑制剂。
Cas No.:2764850-23-7
Sample solution is provided at 25 µL, 10mM.
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LMTK3 inhibitor C28 is a multi-kinase inhibitor.1 It inhibits lemur tyrosine kinase 3 (LMTK3), CDC-like kinase 2 (Clk2), dual-specificity tyrosine phosphorylation-regulated kinase 1α (DYRK1α), homeodomain-interacting protein kinase 2 (HIPK2), and IL-1 receptor-associated kinase 4 (IRAK4; IC50s = 67, 5, 6, 48, and 41 nM, respectively), among others. LMTK3 inhibitor C28 is selective for these kinases over a panel of 122 kinases at 1 ?M. It induces proteasomal degradation of LMTK3 in MCF-7, T47D, and MDA-MB-231 breast cancer cells when used at concentrations of 5 or 10 ?M. LMTK3 inhibitor C28 (10 ?M) reduces the levels of IRAK4, estrogen receptor α (ERα), phosphorylated tropomyosin-related kinase A (TrkA), and HIPK2 in T47D cells. It induces induces apoptosis in MCF-7, T47D, and MDA-MB-231 cells when used at a concentration of 10 ?M. In vivo, LMTK3 inhibitor C28 (10 mg/kg per day) reduces tumor growth and volume in an MDA-MB-231 mouse xenograft model.
References:
[1]. Ditsiou, A., Cilibrasi, C., Simigdala, N., et al.The structure-function relationship of oncogenic LMTK3Sci. Adv.6(46)eabc3099(2020).
| Cas No. | 2764850-23-7 | SDF | |
| 别名 | Lemur Tyrosine Kinase 3-IN-1; Lemur Tyrosine Kinase-IN-C28; Lemur Tyrosine Kinase 3 Inhibitor 1; Lemur Tyrosine Kinase Inhibitor C28; LMTK3-IN-1; LMTK3-IN-C28; LMTK3 Inhibitor 1 | ||
| 化学名 | 6-(4-pyridinyl)-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazine | ||
| Canonical SMILES | FC(F)(OC1=CC=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=C1)F | ||
| 分子式 | C18H11F3N4O | 分子量 | 356.3 |
| 溶解度 | DMSO: Slightly soluble: 0.1-1 mg/ml,Ethanol: Slightly soluble: 0.1-1 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8066 mL | 14.0331 mL | 28.0662 mL |
| 5 mM | 0.5613 mL | 2.8066 mL | 5.6132 mL |
| 10 mM | 0.2807 mL | 1.4033 mL | 2.8066 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet