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Lodoxamide Sale

(Synonyms: 洛度沙胺,U-42585E free acid) 目录号 : GC18282

A potent agonist of GPR35 and a mast cell stabilizer

Lodoxamide Chemical Structure

Cas No.:53882-12-5

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1mg
¥144.00
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5mg
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10mg
¥810.00
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25mg
¥1,258.00
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Description

Lodoxamide is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells[1]. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin[2].

Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys[1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance[3]. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep[4].

References:
[1]. Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94.
[2]. Capron M,et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun;116(2):140-6.
[3]. Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115(3):631-6; discussion 636-7.
[4]. Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76(1):83-90.

化学性质

Cas No. 53882-12-5 SDF
别名 洛度沙胺,U-42585E free acid
化学名 2,2'-[(2-chloro-5-cyano-1,3-phenylene)diimino]bis[2-oxo-acetic acid]
Canonical SMILES ClC1=C(NC(C(O)=O)=O)C=C(C#N)C=C1NC(C(O)=O)=O
分子式 C11H6ClN3O6 分子量 311.6
溶解度 DMSO : 20 mg/mL (36.11 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.2092 mL 16.0462 mL 32.0924 mL
5 mM 0.6418 mL 3.2092 mL 6.4185 mL
10 mM 0.3209 mL 1.6046 mL 3.2092 mL
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