Lorazepam-d4 (CRM)
(Synonyms: Apo-Lorazepam-d4) 目录号 : GC91683Lorazepam-d4 (CRM) is intended for use as an internal standard for the quantification of lorazepam .
Cas No.:84344-15-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
Lorazepam-d4 (CRM) is intended for use as an internal standard for the quantification of lorazepam .2,3 Formulations containing lorazepam have been used in the treatment of anxiety. Lorazepam-d4 is regulated as a Schedule IV compound in the United States. Lorazepam-d4 (CRM) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
References:
[1].Miller, L.G., Greenblatt, D.J., Barnhill, J.G., et al.Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased γ-aminobutyric acidA receptor functionJ. Pharmacol. Exp. Ther.246(1)170-176(1988).
[2].Baldwin, D., Woods, R., Lawson, R., et al.Efficacy of drug treatments for generalised anxiety disorder: Systematic review and meta-analysisBMJ342d1199(2011).
[3].Moosmann, B., Bisel, P., and Auwärter, V.Characterization of the designer benzodiazepine diclazepam and preliminary data on its metabolism and pharmacokineticsDrug Test Anal.6(7-8)757-763(2014).
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.075 mL | 15.3752 mL | 30.7503 mL |
| 5 mM | 0.615 mL | 3.075 mL | 6.1501 mL |
| 10 mM | 0.3075 mL | 1.5375 mL | 3.075 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。