Luotonin F
目录号 : GC15336
A plant alkaloid with anticancer activity
Cas No.:244616-85-1
Sample solution is provided at 25 µL, 10mM.
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Luotonin F is an alkaloid found in the aerial parts of the Peganum nigellastrum Bunge, a plant which has been long used in traditional Chinese medicine for the treatment of rheumatism, abscesses, and various other inflammatory conditions [1].
Due to their biological and pharmaceutical activities, many synthetic methods have been developed for the synthesis of luotonins. An efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin F from easily available starting materials. Through the rational logical design, multifundamental reactions were assembled in one-pot, such as iodination, Kornblum oxidation, and annulations [2]. The developed approach could efficiently synthesize luntonin F and various analogues. Luotonin F showed promising cytotoxicity against leukemia P-388 cells with an IC50 value of 2.3 μg/ml by stabilizing the DNA topoisomerase I-DNA complex [1].
References:
[1] Liang J L, Cha H C, Jahng Y. Recent advances in the studies on luotonins[J]. Molecules, 2011, 16(6): 4861-4883.
[2] Zhu Y, Fei Z, Liu M, et al. Direct one-pot synthesis of Luotonin F and analogues via rational logical design[J]. Organic letters, 2012, 15(2): 378-381.
| Cas No. | 244616-85-1 | SDF | |
| 化学名 | 2-(3-quinolinylcarbonyl)-4(3H)-quinazolinone | ||
| Canonical SMILES | O=C1NC(C(C2=CC(C=CC=C3)=C3N=C2)=O)=NC4=CC=CC=C41 | ||
| 分子式 | C18H11N3O2 | 分子量 | 301.3 |
| 溶解度 | ≤2.5mg/ml in DMSO;2.5mg/ml in dimethyl formamide | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.319 mL | 16.5948 mL | 33.1895 mL |
| 5 mM | 0.6638 mL | 3.319 mL | 6.6379 mL |
| 10 mM | 0.3319 mL | 1.6595 mL | 3.319 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet