Lutein
(Synonyms: 叶黄素) 目录号 : GC44093
A carotenoid with diverse biological activities
Cas No.:127-40-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Lutein is a natural yellow carotenoid, which can be found in plants, egg yolks, and in the human retina. It is a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects. Dietary lutein, in combination with zeaxanthin , vitamins and ω-3 fatty acids, may be beneficial against age-related macular degeneration and cataract development.
| Cas No. | 127-40-2 | SDF | |
| 别名 | 叶黄素 | ||
| Canonical SMILES | O[C@@H]1CC(C)(C)[C@@H](/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C)C[C@@H](O)CC2(C)C)C)C)C(C)=C1 | ||
| 分子式 | C40H56O2 | 分子量 | 568.9 |
| 溶解度 | Chloroform: 5 mg/ml,DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 5 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7578 mL | 8.7889 mL | 17.5778 mL |
| 5 mM | 0.3516 mL | 1.7578 mL | 3.5156 mL |
| 10 mM | 0.1758 mL | 0.8789 mL | 1.7578 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Lutein Supplementation for Eye Diseases
Nutrients 2020 Jun 9;12(6):1721.PMID:32526861DOI:10.3390/nu12061721.
Lutein is one of the few xanthophyll carotenoids that is found in high concentration in the macula of human retina. As de novo synthesis of Lutein within the human body is impossible, Lutein can only be obtained from diet. It is a natural substance abundant in egg yolk and dark green leafy vegetables. Many basic and clinical studies have reported Lutein's anti-oxidative and anti-inflammatory properties in the eye, suggesting its beneficial effects on protection and alleviation of ocular diseases such as age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, myopia, and cataract. Most importantly, Lutein is categorized as Generally Regarded as Safe (GRAS), posing minimal side-effects upon long term consumption. In this review, we will discuss the chemical structure and properties of Lutein as well as its application and safety as a nutritional supplement. Finally, the effects of Lutein consumption on the aforementioned eye diseases will be reviewed.
Potential health benefits of carotenoid Lutein: An updated review
Food Chem Toxicol 2021 Aug;154:112328.PMID:34111488DOI:10.1016/j.fct.2021.112328.
Carotenoids in food substances are believed to have health benefits by lowering the risk of diseases. Lutein, a carotenoid compound, is one of the essential nutrients available in green leafy vegetables (kale, broccoli, spinach, lettuce, and peas), along with other foods, such as eggs. As nutrition plays a pivotal role in maintaining human health, Lutein, as a nutritional substance, confers promising benefits against numerous health issues, including neurological disorders, eye diseases, skin irritation, etc. This review describes the in-depth health beneficial effects of Lutein. As yet, a minimal amount of literature has been undertaken to consider all its promising bioactivities. The step-by-step biosynthesis of Lutein has also been taken into account in this review. Besides, this review demonstrates the drug interactions of Lutein with β-carotene, as well as safety concerns and dosage. The potential benefits of Lutein have been assessed against neurological disorders, eye diseases, cardiac complications, microbial infections, skin irritation, bone decay, etc. Additionally, recent studies ascertained the significance of Lutein nanoformulations in the amelioration of eye disorders, which are also considered in this review. Moreover, a possible approach for the use of Lutein in bioactive functional foods will be discussed.
Lutein: more than just a filter for blue light
Prog Retin Eye Res 2012 Jul;31(4):303-15.PMID:22465791DOI:10.1016/j.preteyeres.2012.03.002.
Lutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. Traditionally Lutein is characterized by its blue light filtering and anti-oxidant properties. Eliminating Lutein from the diet of experimental animals results in early degenerative signs in the retina while patients with an acquired condition of macular pigment loss (Macular Telangiectasia) show serious visual handicap indicating the importance of macular pigment. Whether Lutein intake reduces the risk of age related macular degeneration (AMD) or cataract formation is currently a strong matter of debate and abundant research is carried out to unravel the biological properties of the Lutein molecule. SR-B1 has recently been identified as a Lutein binding protein in the retina and this same receptor plays a role in the selective uptake in the gut. In the blood Lutein is transported via high-density lipoproteins (HDL). Genes controlling SR-B1 and HDL levels predispose to AMD which supports the involvement of cholesterol/Lutein transport pathways. Apart from beneficial effects of Lutein intake on various visual function tests, recent findings show that Lutein can affect immune responses and inflammation. Lutein diminishes the expression of various ocular inflammation models including endotoxin induced uveitis, laser induced choroidal neovascularization, streptozotocin induced diabetes and experimental retinal ischemia and reperfusion. In vitro studies show that Lutein suppresses NF kappa-B activation as well as the expression of iNOS and COX-2. Since AMD has features of a chronic low-grade systemic inflammatory response, attention to the exact role of Lutein in this disease has shifted from a local effect in the eye towards a possible systemic anti-inflammatory function.
Dietary Lutein and Cognitive Function in Adults: A Meta-Analysis of Randomized Controlled Trials
Molecules 2021 Sep 24;26(19):5794.PMID:34641336DOI:10.3390/molecules26195794.
Emerging literature suggests that dietary Lutein may have important functions in cognitive health, but there is not enough data to substantiate its effects in human cognition. The current study was intended to determine the overall effect of Lutein on the main domains of cognition in the adult population based on available placebo randomized-controlled trials. Literature searches were conducted in PubMed, AGRICOLA, Scopus, MEDLINE, and EMBASE on 14 November 2020. The effect of Lutein on complex attention, executive function and memory domains of cognition were assessed by using an inverse-variance meta-analysis of standardized mean differences (SMD) (Hedge's g method). Dietary Lutein was associated with slight improvements in cognitive performance in complex attention (SMD 0.02, 95% CI -0.27 to 0.31), executive function (SMD 0.13, 95% CI -0.26 to 0.51) and memory (SMD 0.03, 95% CI -0.26 to 0.32), but its effect was not significant. Change-from-baseline analysis revealed that Lutein consumption could have a role in maintaining cognitive performance in memory and executive function. Although dietary Lutein did not significantly improve cognitive performance, the evidence across multiple studies suggests that Lutein may nonetheless prevent cognitive decline, especially executive function. More intervention studies are needed to validate the role of Lutein in preventing cognitive decline and in promoting brain health.
Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease
Prog Retin Eye Res 2016 Jan;50:34-66.PMID:26541886DOI:10.1016/j.preteyeres.2015.10.003.
The human macula uniquely concentrates three carotenoids: Lutein, zeaxanthin, and meso-zeaxanthin. Lutein and zeaxanthin must be obtained from dietary sources such as green leafy vegetables and orange and yellow fruits and vegetables, while meso-zeaxanthin is rarely found in diet and is believed to be formed at the macula by metabolic transformations of ingested carotenoids. Epidemiological studies and large-scale clinical trials such as AREDS2 have brought attention to the potential ocular health and functional benefits of these three xanthophyll carotenoids consumed through the diet or supplements, but the basic science and clinical research underlying recommendations for nutritional interventions against age-related macular degeneration and other eye diseases are underappreciated by clinicians and vision researchers alike. In this review article, we first examine the chemistry, biochemistry, biophysics, and physiology of these yellow pigments that are specifically concentrated in the macula lutea through the means of high-affinity binding proteins and specialized transport and metabolic proteins where they play important roles as short-wavelength (blue) light-absorbers and localized, efficient antioxidants in a region at high risk for light-induced oxidative stress. Next, we turn to clinical evidence supporting functional benefits of these carotenoids in normal eyes and for their potential protective actions against ocular disease from infancy to old age.