LY 379268
目录号 : GC14861A selective group II mGlu2/3 receptor agonist
Cas No.:191471-52-0
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
LY 379268 is a highly selective group II mGlu receptor agonist with EC50 value of 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively [1].
mGluRs is a type of glutamate receptor that is being considered as targets for the therapeutic intervention in neurodegenerative disorders. Activation of Group II mGluRs can protect cultured neurones against excitotoxic damage by inhibiting glutamate release [1].
In the CA1 hippocampal cells, LY379268 reduced the ischemia-induced hyperactivity and provided protection after 5-min bilateral carotid artery occlusion (BCAO). Furthermore, before 5-min BCAO, 24- or 48-h pretreatment with LY379268 educed the damage to CA1 hippocampal neurons in a gerbil model [2].
In the gerbil bilateral occlusion of the carotid artery, LY379268 prevented the loss of CA1 hippocampal neurones. Also, LY379268 decreased the BCAO-induced increase in TUNEL positive cells. In the rat model, LY379268 didn’t affect the size of the infarct following middle cerebral artery occlusion (MCAO) [1].
References:
[1]. Bond A, Ragumoorthy N, Monn JA, et al. LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. Neurosci Lett, 1999, 273(3): 191-194.
[2]. Bond A, Jones NM, Hicks CA, et al. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J Pharmacol Exp Ther, 2000, 294(3): 800-809.
| Cas No. | 191471-52-0 | SDF | |
| 化学名 | (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid | ||
| Canonical SMILES | OC([C@@H]1[C@@H]2[C@H]1OC[C@]2(C(O)=O)N)=O | ||
| 分子式 | C7H9NO5 | 分子量 | 187.15 |
| 溶解度 | 25 mM in Water | 储存条件 | Store at 4°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.3433 mL | 26.7165 mL | 53.4331 mL |
| 5 mM | 1.0687 mL | 5.3433 mL | 10.6866 mL |
| 10 mM | 0.5343 mL | 2.6717 mL | 5.3433 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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