LY9 Human
目录号 : GP23851Lymphocyte Antigen 9 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Sf9, Baculovirus cells. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Lymphocyte Antigen 9; Signaling Lymphocytic Activation Molecule 3; Cell Surface Molecule Ly-9; SLAM Family Member 3; SLAMF3; CD229 Antigen; CD229; Hly9; MLY9; LY9. | ||
| Amino Acid Sequence | ADLKDSAPTV VSGILGGSVT LPLNISVDTE IENVIWIGPK NALAFARPKE NVTIMVKSYL GRLDITKWSY SLCISNLTLN DAGSYKAQIN QRNFEVTTEE EFTLFVYEQL QEPQVTMKSV KVSENFSCNI TLMCSVKGAE KSVLYSWTPR EPHASESNGG SILTVSRTPC DPDLPYICTA QNPVSQRSSL PVHVGQFCTD PGASRGGTTG ETVVGVLGEP VTLPLALPAC RDTEKVVWLF NTSIISKERE EAATADPLIK SRDPYKNRVW VSSQDCSLKI SQLKIEDAGP YHAYVCSEAS SVTSMTHVTL LIYRRLRKPK ITWSLRHSED GICRISLTCS VEDGGNTVMY TWTPLQKEAV VSQGESHLNV SWRSSENHPN LTCTASNPVS RSSHQFLSEN ICSGPERNTK HHHHHH | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | LY9 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. | ||
Lymphocyte Antigen 9, also known as LY9 is a member of the SLAM familyof immunomodulatory receptors, LY9 interacts with the adaptor molecule SAP . LY9 plays a part in adhesion reactions between T lymphocytes andaccessory cells via homophilic interaction. LY9 promotes T-cell differentiationinto a helper T-cell Th17 phenotype which leads to increased IL-17 secretion;the costimulatory activity requires SH2D1A. Furthermore it also promotesrecruitment of RORC to the IL-17 promoter. LY9 is implicated in the maintenanceof peripheral cell tolerance through serving as a negative regulator of theimmune response. LY9 disables autoantibody responses as well as inhibitsIFN-gamma secretion by CD4(+) T-cells. Moreover, LY9 negatively regulate thesize of thymic innate CD8(+) T-cells and the development of invariant naturalkiller T (iNKT) cells. Systemic Lupus Erythematosus is one of the diseases whichare associated with LY9.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.