Lythrine
(Synonyms: (+)-Lythrine) 目录号 : GC41178
An alkaloid
Cas No.:5286-10-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Lythrine is an alkaloid originally isolated from H. salicifolia that inhibits prostaglandin synthetase (IC50 = 469 μM).
| Cas No. | 5286-10-2 | SDF | |
| 别名 | (+)-Lythrine | ||
| Canonical SMILES | COC1=CC([C@@]2([H])N3CCCC[C@@]3([H])C[C@@]4([H])C2)=C(C5=CC(/C=C\C(O4)=O)=CC=C5O)C=C1OC | ||
| 分子式 | C26H29NO5 | 分子量 | 435.5 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2962 mL | 11.4811 mL | 22.9621 mL |
| 5 mM | 0.4592 mL | 2.2962 mL | 4.5924 mL |
| 10 mM | 0.2296 mL | 1.1481 mL | 2.2962 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Alkaloids from Heimia salicifolia
Phytochemistry 2008 May;69(8):1756-62.PMID:18374955DOI:10.1016/j.phytochem.2008.01.028.
Two alkaloids, 9beta,2'-dihydroxy-4'',5''-dimethoxy-lythran-12-one or 9beta-hydroxyvertine (1) and (2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate (2), as well as seven known alkaloids, Lythrine (3), dehydrodecodine (4), lythridine (5), vertine (6), heimidine (7), lyfoline (8) and epi-lyfoline (9), were isolated from Heimia salicifolia. The structures of these compounds were elucidated by extensive spectroscopic techniques. Furthermore, the structures of 2, 3, and 6 were confirmed by X-ray crystallography, including absolute configuration determination of 2 and 6. Compounds 6 and 9 showed moderate antimalarial activity.
Heimia salicifolia: a phytochemical and phytopharmacologic review
J Ethnopharmacol 1994 May;42(3):135-59.PMID:7934084DOI:10.1016/0378-8741(94)90080-9.
Heimia salicifolia grows wild from Mexico to Argentina. The aerial parts have a wide folk reputation for antisyphilitic, sudorific, antipyretic, laxative and diuretic activity, and are reported to be useful in preparing post partum baths and to enhance wound healing. Its four most studied alkaloids are vertine, lyfoline, Lythrine and nesodine. Structural relationships of the Heimia alkaloids and certain synthetic 4-arylquinolizidines are reviewed here. Preliminary clinical evaluation indicates that vertine and Lythrine given orally appear to lack the psychodysleptic activity that has been touted for native brews said to incorporate H. salicifolia. Most of the animal studies discussed here have focused on the ataractic, antiinflammatory and antispasmodic potential of vertine and on the hydrodiuretic potential of Lythrine and decine, a structurally related alkaloid found in Decodon verticillatus. The ataractic activity of vertine does not appear to be dependent on the depletion or blockade of catecholamines, while its antiinflammatory capacity seen in both exudative and immunologic systems seems to be dependent in part on an intact pituitary-adrenal system and in part on inhibition of prostaglandin synthase. The antisplasmodic activity of vertine has been demonstrated on many isolated tissues using different agonists, but appears to be largely musculotropic in nature. Only Lythrine and decinine have been shown to be true hydrodiuretics and may prove to be useful in treating Addison's disease and general nephrosis. A number of synthetic 4-arylquinolizidines and related compounds appear to possess antiinflammatory potential.