M-110
目录号 : GC34138M-110是Pim激酶抑制剂,抑制前列腺癌细胞系增殖IC50为0.6-0.9uM。
Cas No.:1395048-49-3
Sample solution is provided at 25 µL, 10mM.
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- Purity: >98.50%
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M-110 is a novel and highly selective inhibitor of PIM kinases; inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 uM, with no activity on normal human peripheral blood mononuclear cells up to 40 uM.IC50 value:Target: Pim inhibitorin vitro: Treatment of DU-145 cells with M-110 or with a structurally unrelated PIM inhibitor, SGI-1776, significantly reduces pSTAT3Tyr705 expression without affecting the expression of STAT3. Furthermore, treatment of DU-145 cells with M-110 attenuates the interleukin-6-induced increase in pSTAT3Tyr705 [1]. M-110 treatment of APC-mutant DLD-1 cells, preferentially attenuated constitutive TOPFLASH activity as compared with FOPFLASH, and had no effect on the CMV-β-galactosidase control reporter. In SW480 cells, M-110 also decreased the levels of free cytoplasmic β-catenin as determined by E-cadherin pull down assays. M-110 also blocked Wnt signaling when other destruction complex components were disrupted, including abrogation of AXIN1/2 expression using siRNAs or inhibition of GSK3β activity using LiCl or I3M [2].
[1]. He Y, et al. Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways. Biochem Biophys Res Commun. 2014 Jul 4;449(3):344-50. [2]. Zhou E, et al. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Int Immunopharmacol. 2014 Sep;22(1):133-40. [3]. Sa F, et al. Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo. Neurosci Lett. 2015 Apr 23;593:7-12. [4]. Zhang LQ, et al. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. J Ethnopharmacol. 2015 Apr 29. pii: S0378-8741(15)00306-2.
Cas No. | 1395048-49-3 | SDF | |
Canonical SMILES | O=C(N/N=C(C1=CC=C(Cl)C=C1O)\CC)C2=CC(NCCCN3CCOCC3)=NC=C2 | ||
分子式 | C22H28ClN5O3 | 分子量 | 445.94 |
溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
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1 mg | 5 mg | 10 mg | |
1 mM | 2.2425 mL | 11.2123 mL | 22.4245 mL |
5 mM | 0.4485 mL | 2.2425 mL | 4.4849 mL |
10 mM | 0.2242 mL | 1.1212 mL | 2.2425 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Topologically distinct Weyl fermion pairs
A Weyl semimetal has Weyl nodes that always come in pairs with opposite chiralities. Notably, different ways of connection between nodes are possible and would lead to distinct topologies. Here we identify their differences in many respects from two proposed models with different vorticities. One prominent feature is the behaviour of zeroth Landau levels (LLs) under magnetic field. We demonstrate that the magnetic tunneling does not always expel LLs from zero energy because the number of zero-energy modes is protected by the vorticity of the Weyl nodes, instead of the chirality. Other respects in disorder effects for weak (anti-)localization, surface Fermi arcs, and Weyl-node annihilation, are interesting consequences that await more investigation in the future.
Compact MZI modulators on thin film Z-cut lithium niobate
In this paper, we designed, implemented, and characterized compact Mach-Zehnder interferometer-based electro-optic modulators. The modulator utilizes spiral-shaped optical waveguides on Z-cut lithium niobate and the preeminent electro-optic effect which is applied using top and bottom electrodes. Optical waveguides are made of rib etched lithium niobate waveguides with bottom silicon oxide cladding, while SU8 polymer covers the top and sides of the rib waveguides. The proposed implementation resulted in low optical losses < 1.3 dB/cm. Moreover, we achieved compact modulators that fit 0.286 cm and 2 cm long optical waveguides in 110 ?m × 110 ?m and 300 ?m × 300 ?m areas, respectively. For single arm modulation, the modulators achieved a VπL of 7.4 V.cm and 6.4 V.cm and 3-dB bandwidths of 9.3 GHz and 2.05 GHz, respectively. Push-pull modulation is expected to cut these VπL in half. The proposed configuration avoids traveling wave modulation complexities and represents a key development towards miniature and highly integrated photonic circuits.
Near-Infrared-II Semiconducting Polymer Dots for Deep-tissue Fluorescence Imaging
Fluorescence imaging, particularly in the NIR-II region (1000-1700 nm), has become an unprecedented tool for deep-tissue in vivo imaging. Among the fluorescent nanoprobes, semiconducting polymer nanoparticles (Pdots) appear to be a promising agent because of their tunable optical and photophysical properties, ultrahigh brightness, minimal autofluorescence, narrow-size distribution, and low cytotoxicity. This review elucidates the recent advances in Pdots for deep-tissue fluorescence imaging and the facing future translation to clinical use.
Effects of titanium with different micro/nano structures on the ability of osteoblasts to resist oxidative stress
Excessive accumulation of oxidative intermediates in the elderly significantly aggravates bone degradation and hinders the osseointegration of topological titanium (Ti) implants. Thus, it is of great significance to evaluate the antioxidant and osteoinduction capabilities of various nano, micro or micro/nano-composite structures under oxidative stress (OS) microenvironment. In this study, we discovered that 110 nm titania nanotubes (TNTs) enhanced the adsorption of fibronectin (FN) proteins onto smooth and rough titanium surfaces to varying degrees. Compared with Ti and 30 nm TNTs (T30) groups, cells on 110 nm TNTs (T110), microstructure/30 nm TNTs (M30) and microstructure/110 nm TNTs (M110) had smaller area, lower reactive oxygen species (ROS), and better proliferation/osteogenic differentiation abilities under OS condition, but there was no significant difference among the three groups. In addition, combined with our previous study, we suggested that T110, M30 and M110 resistance to OS was also strongly associated with the high expression of FN-receptor integrin α5 or β1. All the findings indicated that the micro/nano-composed structures (M30 & M110) had similar anti-oxidation and osteogenesis abilities to T110, which provided guidance for the application of different titanium implants with different topologies in the elderly.
Spatial variability of outdoor exposure to radiofrequency radiation from mobile phone base stations, in Khartoum, Sudan
The wide-spread exposure to constantly evolving wireless technologies believed to pose a serious health threat. Human beings are persistently exposed to RF radiation from mobile phones and their base stations. The current study aimed at classifying and characterizing the exposure to RF radiation from the mobile phone base stations. Spatial distribution measurements were carried out in Khartoum city during two time periods, first in 2012 (pilot survey) and again during Sept. 2019-Jan. 2020, to cover a total of 282 antennas operating with GSM900, GSM1800, and UMTS2100. The tested antennas belong to three mobile communication companies namely Sudani, Zain, and MTN companies, that randomly coded into company A, company B, and company C for security purposes. Measurements were performed using frequency-selective RF analyzer at fixed distances from the antennas/towers. Data were subjected to advanced repeated measures ANOVA, linear discriminant analysis (LDA), and spatial interpolation with ArcGIS. The averages of GSM900, GSM1800, and UMTS measurements were 0.01933 W/m2, 0.0067 W/m2, and 0.0046 W/m2. The high levels of power densities for each single antenna were recorded at 90 m, 110 m, 130 m, and at 150 m distances, for the majority (70%) of the measured antennas and the peak/highest values reported mainly at 110 m distance. Conversely, the discriminant loadings as part of LDA, suggested that, much of variance among measurements is attributed to measurements at 150 m, 170 m, and 190 m distances, while visual illustration of group centroids implied that, the RF signals of the different companies were measured separately which support accuracy of frequency-selective measurements. The LDA has confirmed the ANOVA results that, the overall difference between the three companies was statistically significant for UMTS, and GSM900 measurements but not significant for GSM1800 measurements. Kriging interpolation using ArcGIS provided a strong evidence of great spatial distribution of exposure across the study area, with market places and typical urban residential quarters showing highest levels of RF. Few extreme values exceeding ICNIRP limits are reported but excluded from the calculations because of an issue of normality of data that is considered a prerequisite for parametric data analysis. Existence of extreme levels of RF indicates a need for further investigation and some antennas of Company B are mounted on towers belongs to Company C, implying multi exposure. Unexpected pattern of RF levels continued to increase up to 190 m distance and possibly beyond 190 m is reported for UMTS measurements of Company C.