M190S
目录号 : GC73619M190S是一种新型小分子，在体外和体内保护细胞免受线粒体依赖性凋亡。
Cas No.:2578300-07-7
Sample solution is provided at 25 µL, 10mM.
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M190S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo. M190S has the potential to become a research tool for studying cell death mechanisms and to develop therapeutics targeting mitochondria-dependent cell death pathway. M190S has orally bioactivity with excellent brain permeability.
M190S (0.1-10000 nM, 24-48 h) inhibits apoptosis induced by Bax as well as Bak[1].M190S (0-10μM, 4 h) suppresses Staurosporine -induced apoptosis in MEFs [1].M190S (0-10μM, 24 h) inhibits Etoposide -induced apoptosis in Neuro2a cells[1].M190S (500 nM, 24 h) inhibits Obatoclax -induced apoptosis in ARPE19 cells[1].M190S (500 nM, 48 h) suppresses the conformation change (N-terminal exposure) and mitochondrial translocation of Bax[1].M190S (1.0 μM, 4h) decreases mitochondrial oxygen consumption and reactive oxygen species, whereas M190S (0.1-1 nM, 4 h) increases glycolysis[1].
M190S (10mg/kg p.o., three time in 48 h) protects the retina from the bright-light-induced photoreceptor death[1].M190S (1 mg/kg, i.p., i.v., 5 mg/kg, o.p. 10 mg/kg 1 time) is an orally bioactive cell death inhibitor penetrating blood-brain/retina-barrier[1].
References:
[1]. Mieko Matsuyama, et al. Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death. Science 26, 107916, October 20, 2023
| Cas No. | 2578300-07-7 | SDF | |
| 分子式 | C21H21N5O2 | 分子量 | 375.42 |
| 溶解度 | DMSO : 100 mg/mL (266.37 mM; Need ultrasonic) | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6637 mL | 13.3184 mL | 26.6368 mL |
| 5 mM | 0.5327 mL | 2.6637 mL | 5.3274 mL |
| 10 mM | 0.2664 mL | 1.3318 mL | 2.6637 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet