Magnolin

Magnolin is a lignan originally found in M. fargesii that has anti-inflammatory and anticancer activities.¹ It inhibits LPS-induced nitric oxide (NO) production in BV-2 cells (IC₅₀ = 20.5 ?M).² Magnolin inhibits ERK1 and ERK2 (IC₅₀s = 87 and 16.5 nM, respectively) and EGF-induced NF-κB transactivation activity when used at concentrations of 30 and 60 ?M.³ It suppresses migration of JB6 C141 cells in a concentration-dependent manner and decreases markers of epithelial-to-mesenchymal transition (EMT) in A549 cells. Magnolin decreases phosphorylation of Akt, increases caspase-3 levels, and upregulates p53 and p21 in PC3 and DU145 prostate cancer cells.⁴ It inhibits proliferation, halts the cell cycle, and induces apoptosis in PC3 and DU145 cells when used at concentrations of 50 and 100 ?M. Magnolin also reduces tumor growth and increases apoptosis of tumor cells in a PC3 prostate cancer mouse xenograft model when administered at a dose of 50 ?mol/kg.

1.Kakisawa, H., Kusumi, T., Hsu, H.-Y., et al.Structures of lignans of Magnolia fargesiiBull. Chem. Soc. Jpn.43(11)3631-3631(1970) 2.Kim, J.Y., Lim, H.J., Lee, D.Y., et al.In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesiiBioorg. Med. Chem. Lett.19(3)937-940(2009) 3.Lee, C.-J., Lee, M.-H., Yoo, S.-M., et al.Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathwayBMC Cancer15:576(2015) 4.Huang, Y., Zou, X., Zhang, X., et al.Magnolin inhibits prostate cancer cell growth in vitro and in vivoBiomed Pharmacother.87714-720(2017)