Mal-PEG2-Val-Cit-PABA-PNP

Mal-PEG2-Val-Cit-PABA-PNP is a cleavable ADC linker containing two PEG units, which can be used in the synthesis of antibody-drug conjugates (ADCs) [1].

Mal-PEG2-Val-Cit-PABA-PNP (CAS:1345681-52-8) is a small molecule drug that contains several functional groups. The Mal group, which is a reactive functional group, can specifically react with thiol groups on proteins. This characteristic enables the drug to target specific proteins in the body. The PEG2 group is a polyethylene glycol spacer that can enhance the solubility and stability of the drug in solution. Val and Cit groups are amino acids that help form a peptide bond, which is an essential structural component of the drug. The PABA group can be used to link the drug to other molecules, and the PNP group serves as a leaving group in chemical reactions.

This combination of Mal-PEG2-Val-Cit-PABA-PNP functional groups is designed to create a drug that can target specific proteins or biological processes in the body. For instance, the Mal group can specifically target overexpressed proteins in certain types of cancer cells, leading to more effective treatment. The PEG2 spacer can improve the pharmacokinetic properties of the drug, while the amino acid groups contribute to the drug's stability. The PABA group can be used to link the drug to other molecules such as antibodies, creating a more precise and targeted therapy.

Mal-PEG2-Val-Cit-PABA-PNP(CAS:1345681-52-8)是一种由几种功能基团组成的小分子药物。其中,Mal(马来酰亚胺)基团是一种功能基团,可以特异性地与蛋白质上的巯基发生反应,使药物能够针对特定蛋白质进行定位。PEG2基团是聚乙二醇间隔基,可以提高药物在溶液中的溶解度和稳定性。Val和Cit基团是氨基酸,用于形成肽键,是药物的重要结构组成部分。PABA基团是一种功能基团,可用于将药物与其他分子链接,而PNP基团则用作化学反应中的离去基团。

这些功能基团的组合旨在创建一种药物,可以针对身体中特定的蛋白质或生物过程。例如,Mal基团可以将药物定位到某些癌细胞中过度表达的蛋白质,从而实现更精确和有效的治疗。PEG2间隔基可以改善药物的药代动力学特性,而氨基酸基团则用于创建肽键,增加药物在体内的稳定性。PABA基团可以用于将药物与其他分子(如抗体)链接起来,以创建更加精确和针对性的治疗方案。

References:
[1]. Beck A, Goetsch L, Dumontet C, CorvaÏa N. Strategies and challenges for the next generation of antibody-drug conjugates. Nature reviews Drug discovery. 2017 May;16(5):315-37.